Evidence map›Paper›PMID 41155404›Full record

ArticleInternational journal of molecular sciences2025

Plasma Protein Biomarkers to Detect Early Gastric Preneoplasia and Cancer: A Prospective Study.

Quentin Giai Gianetto, Valérie Michel, Thibaut Douché, Karine Nozeret, Aziz Zaanan, Oriane Colussi, Isabelle Trouilloud, Simon Pernot, Marie-Noelle Ungeheuer, Catherine Julié and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Quentin Giai GianettoInstitut Pasteur, Université Paris Cité, UAR CNRS 2024, Proteomics Core Facility, MSBio, 75015 Paris, France.ORCID 0000-0001-6815-2498
Valérie MichelInstitut Pasteur, Université Paris Cité, CNRS UMR 6047, Infection, Genotoxicity and Cancer Team, 75015 Paris, France.
Thibaut DouchéInstitut Pasteur, Université Paris Cité, UAR CNRS 2024, Proteomics Core Facility, MSBio, 75015 Paris, France.ORCID 0000-0001-8627-6726
Karine NozeretInstitut Pasteur, Université Paris Cité, CNRS UMR 6047, Infection, Genotoxicity and Cancer Team, 75015 Paris, France.ORCID 0009-0000-4284-9991
Aziz ZaananAssitance Publique-Hôpitaux de Paris, Université Paris-Cité, Georges Pompidou European Hospital, Department of Gastroenterology and Digestive Oncology, 75015 Paris, France.
Oriane ColussiAssitance Publique-Hôpitaux de Paris, Université Paris-Cité, Georges Pompidou European Hospital, Department of Gastroenterology and Digestive Oncology, 75015 Paris, France.
Isabelle TrouilloudAssitance Publique-Hôpitaux de Paris, Université Paris-Cité, Georges Pompidou European Hospital, Department of Gastroenterology and Digestive Oncology, 75015 Paris, France.
Simon PernotAssitance Publique-Hôpitaux de Paris, Université Paris-Cité, Georges Pompidou European Hospital, Department of Gastroenterology and Digestive Oncology, 75015 Paris, France.
Marie-Noelle UngeheuerInstitut Pasteur, Center for Translational Research, Clinical Investigation and Access to Clinical Resources (ICAReB), 75015 Paris, France.
Catherine JuliéAssistance Publique-Hôpitaux de Paris, CHU Paris IdF Ouest, Pathology Unit Ambroise Paré Hospital, 92100 Boulogne Billancourt, France.
Nathalie JollyInstitut Pasteur, Université Paris Cité, Clinical Research Coordination Office, 75015 Paris, France.
Julien TaïebAssitance Publique-Hôpitaux de Paris, Université Paris-Cité, Georges Pompidou European Hospital, Department of Gastroenterology and Digestive Oncology, 75015 Paris, France.ORCID 0000-0002-9955-4753
Dominique LamarqueAssistance Publique-Hôpitaux de Paris CHU Paris IdF Ouest, Unit of Hepato-Gastroenterology, Ambroise Paré Hospital, 92100 Boulogne-Billancourt, France.
Mariette MatondoInstitut Pasteur, Université Paris Cité, UAR CNRS 2024, Proteomics Core Facility, MSBio, 75015 Paris, France.ORCID 0000-0003-3958-7710
Eliette TouatiInstitut Pasteur, Université Paris Cité, CNRS UMR 6047, Infection, Genotoxicity and Cancer Team, 75015 Paris, France.ORCID 0000-0002-3450-1773

Funding

Institut Pasteur ACIP2015-10Institut Pasteur INNOV-80-20Odyssey-Re
6 · The paper itself

Abstract

Gastric cancer (GC) often presents a poor prognosis due to its asymptomatic phenotype at early stages. Upper endoscopy, which is the current gold standard to diagnose GC, is invasive with limited sensitivity for detecting gastric preneoplasia. Non-invasive biomarkers, such as blood circulating proteins, offer a promising alternative for the early detection of gastric lesions. In this prospective study, we identified plasma protein biomarkers for gastric preneoplasia and cancer using mass spectrometry-based proteomics in an exploratory cohort (n = 39). Fifteen promising protein candidates emerged to distinguish patient categories and were further confirmed by enzyme-linked immunosorbent assays (ELISA) in plasma samples from a validation cohort of 138 participants. Our predictive models demonstrated high classification performance with a minimal set of biomarkers. A four-protein panel (ARG1, CA2, F13A1, S100A12) achieved 94.1-98.2% AUROC (95% CI) for distinguishing cancer from non-cancer cases, while a five-protein panel (ARG1, CA2, HPT, MAN2A1, LBP) reached 97.3-99.5% AUROC (95% CI) for distinguishing cancer or preneoplasia from healthy or non-atrophic gastritis cases on the full cohort. Leveraging simple blood sampling, this strategy holds promise to detect high-risk gastric lesions, even at asymptomatic stages. Such an approach could significantly improve early detection and clinical management of GC, offering direct benefit for patients.

Indexed as

Biomarkers, TumorBlood ProteinsPrecancerous ConditionsStomach NeoplasmsAdultAgedEarly Detection of CancerFemaleHumansMaleMiddle AgedProspective StudiesProteomicsBiomarkers, TumorBlood Proteinsdiagnosisdysplasiaearly detectiongastric cancerintestinal metaplasialiquid biopsymass spectrometry-based proteomicpreventive strategies

Identifiers

PMID41155404
PMCPMC12564110

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.