Evidence map›Paper›PMID 41155459›Full record

ArticleInternational journal of molecular sciences2025

Differential Expression of Complement Pathway Components in Unexplained Infertility Versus Male Factor Infertility: Insights from an Exploratory Pilot Study.

Edwina Brennan, Marya K E A Radhi, Zainab A A H Husain, Thozhukat Sathyapalan, Abu Saleh Md Moin, Alexandra E Butler, Stephen L Atkin

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Edwina BrennanSchool of Medicine, Royal College of Surgeons in Ireland Bahrain, Adliya 15503, Bahrain.ORCID 0000-0003-0183-4683
Marya K E A RadhiSchool of Medicine, Royal College of Surgeons in Ireland Bahrain, Adliya 15503, Bahrain.ORCID 0009-0006-6546-3526
Zainab A A H HusainSchool of Medicine, Royal College of Surgeons in Ireland Bahrain, Adliya 15503, Bahrain.
Thozhukat SathyapalanAcademic Endocrinology, Diabetes and Metabolism, Hull York Medical School, University of Hull, Hull HU6 7RU, UK.ORCID 0000-0003-3544-2231
Abu Saleh Md MoinSchool of Medicine, Royal College of Surgeons in Ireland Bahrain, Adliya 15503, Bahrain.ORCID 0000-0002-5342-2501
Alexandra E ButlerSchool of Medicine, Royal College of Surgeons in Ireland Bahrain, Adliya 15503, Bahrain.ORCID 0000-0002-5762-3917
Stephen L AtkinSchool of Medicine, Royal College of Surgeons in Ireland Bahrain, Adliya 15503, Bahrain.ORCID 0000-0002-5887-7257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complement (C) proteins have been linked to infertility and reproductive outcomes. This study was undertaken to determine the association of complement proteins in non-obese women before in vitro fertilization (IVF) with unexplained infertility (UI) compared to women with male factor infertility (MFI) as controls. We hypothesized that complement protein factors may provide evidence for the underlying mechanism in UI. In this exploratory pilot study, 25 women (UI = 14 and MFI = 11) undergoing IVF had blood drawn on day 21 of the luteal phase. Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement was undertaken for 25 complement pathway-related proteins. Student's

Indexed as

Complement System ProteinsInfertility, FemaleInfertility, MaleAdultFemaleFertilization in VitroHumansMalePilot ProjectsComplement System ProteinsC3adesArgC4C8complement pathwaysinfertilityproperdinunexplained infertility

Identifiers

PMID41155459
PMCPMC12562869

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.