Evidence map›Paper›PMID 41155519›Full record

ArticleInternational journal of molecular sciences2025

Berbamine Targets TNFAIP3: A Bioactive Compound Alleviates Oxidative Stress and Inflammation in the Comorbidity of Insomnia and Chronic Obstructive Pulmonary Disease Through Multi-Omics Integration.

Xinliao Deng, Shuaiyu Jiang, Ziyi Liu, Xinyu Liu, Tao Lu, Xiaodan Liu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinliao DengSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Shuaiyu JiangSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID 0009-0008-8699-6588
Ziyi LiuSchool of Traditional Chinese Medicine, Shanxi Datong University, Datong 037009, China.ORCID 0009-0002-0157-456X
Xinyu LiuSchool of Traditional Chinese Medicine, Shanxi Datong University, Datong 037009, China.
Tao LuSchool of Traditional Chinese Medicine, Shanxi Datong University, Datong 037009, China.ORCID 0000-0003-4354-7367
Xiaodan LiuSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID 0000-0002-8379-0292

Funding

Da Tong Key Research Project of Science and Technology Planning 2024025Health Discipline Leader Project of Shanghai Municipal Health Commission 2022XD044National Natural Science Foundation of China 82072551National Natural Science Foundation of China 82372573
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) and insomnia are highly comorbid, yet their shared pathogenesis and therapeutic targets remain unclear. This study employed multidimensional approaches-including bidirectional Mendelian randomization (MR), transcriptomic analysis, weighted gene co-expression network analysis (WGCNA), and computational drug repositioning-to investigate causal relationships, shared pathways, and therapeutic strategies for COPD-insomnia comorbidity. MR analysis indicated that insomnia is a causal risk factor for COPD (OR = 2.04, 95% CI: 1.18-3.51;

Indexed as

InflammationOxidative StressPulmonary Disease, Chronic ObstructiveSleep Initiation and Maintenance DisordersTumor Necrosis Factor alpha-Induced Protein 3ComorbidityDrug RepositioningGene Expression ProfilingGene Regulatory NetworksHumansMendelian Randomization AnalysisMolecular Docking SimulationMultiomicsProtein Interaction MapsTNFAIP3 protein, humanTumor Necrosis Factor alpha-Induced Protein 3chronic obstructive pulmonary diseasecomorbidity mechanismsinsomniamendelian randomizationnatural small molecule compounds

Identifiers

PMID41155519
PMCPMC12563523

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.