Evidence map›Paper›PMID 41155640›Full record

ReviewPharmaceuticals (Basel, Switzerland)2025

Wound Healing: Molecular Mechanisms, Antimicrobial Peptides, and Emerging Technologies in Regenerative Medicine.

Ana Paula de Araújo Boleti, Ana Cristina Jacobowski, Breno Emanuel Farias Frihling, Maurício Vicente Cruz, Kristiane Fanti Del Pino Santos, Ludovico Migliolo, Lucas Rannier Melo de Andrade, Maria Ligia Rodrigues Macedo

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Thromborepair: the tissue repair partner to thromboinflammation.Blood vessels, thrombosis & hemostasis · 2026
    Review
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  14. High-Frequency Ultrasound Evaluation of Cutaneous Surgical Wound Healing: An Outpatient Experience.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ana Paula de Araújo BoletiProtein Purification and Biological Functions Laboratory, Food Technology and Public Health Unit, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, Brazil.
Ana Cristina JacobowskiProtein Purification and Biological Functions Laboratory, Food Technology and Public Health Unit, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, Brazil.ORCID 0000-0001-8233-0713
Breno Emanuel Farias FrihlingProtein Purification and Biological Functions Laboratory, Food Technology and Public Health Unit, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, Brazil.
Maurício Vicente CruzProtein Purification and Biological Functions Laboratory, Food Technology and Public Health Unit, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, Brazil.
Kristiane Fanti Del Pino SantosProtein Purification and Biological Functions Laboratory, Food Technology and Public Health Unit, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, Brazil.ORCID 0000-0003-2162-5483
Ludovico MiglioloS-Inova Biotech, Postgraduate Program in Biotechnology, Dom Bosco Catholic University, Campo Grande 79117-900, Brazil.ORCID 0000-0002-6606-2189
Lucas Rannier Melo de AndradeProtein Purification and Biological Functions Laboratory, Food Technology and Public Health Unit, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, Brazil.ORCID 0000-0001-8866-2030
Maria Ligia Rodrigues MacedoProtein Purification and Biological Functions Laboratory, Food Technology and Public Health Unit, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, Brazil.ORCID 0000-0001-6969-6307

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is a dynamic process involving distinct phases that are regulated by cellular and molecular interactions. This review explores the fundamental mechanisms involved in wound healing, including the roles of cytokines and growth factors within the local microenvironment, with a particular focus on antimicrobial peptides (AMPs) as immune modulators and therapeutic agents in chronic wounds. Notably, AMPs such as LL-37 have been shown to reduce biofilm density by up to 60%, highlighting their dual role in both modulating host immune responses and combating persistent bacterial infections. It further examines emerging technologies that are transforming the field, extending beyond traditional biological mechanisms to innovations such as smart dressings, 3D bioprinting, AI-driven therapies, regenerative medicine, gene therapy, and organoid models. Additionally, the review addresses strategies to overcome bacterial biofilms and highlights promising approaches including biomaterials, nanomedicine, gene therapy, peptide-loaded nanoparticles, and the application of organoids as advanced platforms for studying and enhancing wound repair.

Indexed as

antimicrobial peptidesartificial intelligencebiofilmgene therapynanotechnologytissue regeneration

Identifiers

PMID41155640
PMCPMC12567145

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.