Evidence map›Paper›PMID 41156476›Full record

ArticleNutrients2025

Quercetin as a Bitter Taste Receptor Agonist with Anticancer Effects in Head and Neck Cancer Cells.

Gavin Turner, Sarah M Sywanycz, Brianna L Buchler, Robert D Wardlow, Robert J Lee, Ryan M Carey

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Gavin TurnerDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.
Sarah M SywanyczDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.
Brianna L BuchlerDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.
Robert D WardlowDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.
Robert J LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.ORCID 0000-0001-5826-6686
Ryan M CareyDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.ORCID 0000-0002-0186-2265

Funding

Immune function of bitter taste receptors in human macrophagesR01AI167971 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Nithin Adappa, Robert J. Lee · 2022 to 2026
$2.5M
Bitter taste receptors in oral cancer tumor-associated macrophagesR01DE034474 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI Ryan Michael Carey · 2025 to 2026
$1.0M
NIAID NIH HHS R01 AI167971NIDCR NIH HHS R01 DE034474NIH HHS 1R01DE034474-01A1NIH HHS 5R01AI167971-04Perelman School of Medicine at the University of Pennsylvania McCabe Foundation Fellowship Grant
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsHead and Neck NeoplasmsQuercetinReceptors, G-Protein-CoupledSquamous Cell Carcinoma of Head and NeckApoptosisCalciumCell Line, TumorCell SurvivalHumansTaste Receptors, Type 2Antineoplastic AgentsCalciumQuercetinReceptors, G-Protein-CoupledTaste Receptors, Type 2anticancerbitter taste receptorscalcium responsehead and neck squamous cell carcinomamitochondrial depolarizationquercetinT2R14

Identifiers

PMID41156476
PMCPMC12567344

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.