Evidence map›Paper›PMID 41156629›Full record

SynthesisPathogens (Basel, Switzerland)2025

Neutrophil Extracellular Traps in Viral Infections.

Jiajun Chen, Rong He, Jirong Luo, Shilu Yan, Wenbo Zhu, Shuangquan Liu

Abstract readSystematic Review
In one paragraph

Synthesis in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiajun ChenDepartment of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.ORCID 0009-0007-7450-4585
Rong HeDepartment of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.
Jirong LuoDepartment of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.
Shilu YanDepartment of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.
Wenbo ZhuClinical Medical Research Center, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.ORCID 0000-0002-2637-564X
Shuangquan LiuDepartment of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.ORCID 0000-0002-2690-2665

Funding

Clinical "4310" Project of the University of South China 20224310NHYCG02Hengyang Key Laboratory of Molecular Diagnosis of Infectious Diseases 202010041571Key research and development (R&D) of Hunan Province 2024JK2118
6 · The paper itself

Abstract

Neutrophils are the most abundant immune cells in the human body. Neutrophil extracellular traps (NETs) have recently garnered significant attention as a novel, non-traditional mechanism for combating pathogenic microorganisms. Recent studies have shown that NETs play a crucial role in antiviral immunity, providing new perspectives on how neutrophils defend against viral invasion. Viruses not only induce NET formation through various mechanisms but have also developed multiple escape strategies targeting NETs. It is worth noting that NETs are a double-edged sword for the host: while they possess antiviral effects that inhibit viral spread and replication, their constituent components may also exacerbate tissue damage and play important pathological roles in the progression of certain viral infections. Therefore, a thorough understanding of the regulatory mechanisms and dynamic balance of NETs in viral infections is of critical importance. Additionally, since the components of NETs may vary depending on the stimulus, NET-related markers have the potential to serve as biomarkers for the severity and prognosis of viral diseases. This article provides a systematic review of the induction mechanisms, antiviral effects, viral escape strategies, and virus-induced NET-related immunopathological damage in viral infections, offering new insights for antiviral immunotherapy.

Indexed as

Extracellular TrapsHost-Pathogen InteractionsNeutrophilsVirus DiseasesAnimalsHumansVirusesimmune evasionsimmunologic injuryneutrophilneutrophil extracellular trapsviral infections

Identifiers

PMID41156629
PMCPMC12567399

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.