ReviewLife (Basel, Switzerland)2025
Interplay Between Aging and Glial Cell Dysfunction: Implications for CNS Health.
Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Differential effects of environmental enrichment and physical exercise on glial biology in aging and aging-related conditions: a systematic review.Frontiers in cellular neuroscience · 2026Pooled it
- The Dual Role of Macroglia in Glaucoma: Deciphering the Contributions of Astrocytes and Müller Cells to Retinal Neurodegeneration and Neuroprotection.International journal of molecular sciences · 2026Review
- Unlocking the aging brain: mTORC1 as a convergent integrator for neurodegeneration and therapeutic intervention.Biogerontology · 2026Review
- Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation.Neurology international · 2026Review
- Mas-Related G-Protein-Coupled Receptors: Emerging Roles in Neuropathic Pain.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is accompanied by complex cellular and molecular changes that compromise CNS function. Among these, glial cells (astrocytes, microglia, and oligodendrocytes) play a central role in maintaining neural homeostasis, modulating synaptic activity, and supporting metabolic demands. Emerging evidence indicates that aging disrupts glial cell physiology through processes including mitochondrial dysfunction, impaired proteostasis, chronic low-grade inflammation, and altered intercellular signaling. These alterations contribute to synaptic decline, myelin degeneration, and persistent, low-grade inflammation of the CNS. This review synthesizes current knowledge on the bidirectional relationship between aging and glial cell dysfunction, highlighting how age-related systemic and CNS-specific factors exacerbate glial impairments and, in turn, accelerate neural deterioration. Finally, this study discusses some potential therapeutic strategies aimed at preserving or restoring glial function to promote CNS resilience in aging populations. Understanding this interplay offers critical opportunities for mitigating cognitive decline and improving quality of life in older adults.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.