ArticleThe veterinary quarterly2025
Glycolytic reprogramming impairs chondrocyte function in broilers with femoral head necrosis.
Article in The veterinary quarterly, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Restoring glucose metabolic homeostasis to attenuate ovarian aging: mechanisms and clinical prospects.Journal of ovarian research · 2026Review
- Energy crisis and cartilage collapse: metabolic reprogramming of chondrocytes in osteoarthritis.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cartilage extracellular matrix (ECM) destruction is a hallmark of femoral head necrosis (FHN) in broilers. Chondrocytes undergo metabolic reprogramming under stress to maintain function. However, the metabolic alterations in FHN chondrocytes remain unclear. This study aims to investigate the overall changes of metabolic state in FHN chondrocytes and its functions. Femoral head cartilage of healthy and FHN broilers was collected for non-targeted metabolome and transcriptome analyses. Additionally, primary chondrocytes were isolated from femoral head cartilage of control (CON) and FHN broilers for bioenergetic analysis and mechanistic investigation. Multi-omics profiling revealed significant enrichment of the glycolysis pathway, decreased levels of tricarboxylic acid cycle metabolites (citrate and malate), upregulation of the lactate dehydrogenase A (
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Registered trials
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