SynthesisFrontiers in pharmacology2025
Therapeutic efficacy of botanicals in psychological disorders in menopausal women: a systematic and scoping review.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Next-Generation Redox Mediators: Itaconate, Nitro-Fatty Acids, Reactive Sulfur Species and Succinate as Emerging Switches in Predictive Redox Medicine.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Understanding the emotional impact of menopause on women is of utmost importance, especially with the predictable estimate of 1.2 billion menopausal women globally by 2030. Depression, anxiety, and stress are common during menopause, and botanical medicines, particularly from Unani traditions, may offer effective, natural therapeutic options. This study combines systematic and scoping review methods to assess the clinical efficacy of botanical interventions and map the broader research landscape. Methods: A comprehensive literature search was conducted across PubMed, Science Direct and PROSPERO from 2000 to 2024, following both PRISMA 2020 and PRISMA-ScR guidelines. The scoping phase identified a wide range of botanicals and research trends, while the systematic review focused on randomized controlled trials evaluating efficacy. Cochrane risk-of-bias tool was used for methodological quality assessment. Network visualization and word cloud techniques were also employed to identify related terms from the prior studies included in the analysis. Results: Sixteen RCTs involving 1,112 participants (mean age ±SD: 69.5 ± 21.88) were included. Most studies had a low risk of bias. Bioactive compounds such as withaferin A, quercetin, rosmarinic acid, and thymoquinone demonstrated antidepressant, anxiolytic, and neuroprotective effects through antioxidant, anti-inflammatory, GABAergic, and serotonergic mechanisms. Machine learning approaches showed potential for identifying compound interactions and personalizing treatment. Conclusion: Botanical medicines, especially from the Unani system, show promising efficacy in managing psychological symptoms during menopause. While current evidence is encouraging, further robust trials and mechanistic studies are needed. The integration of machine learning offers a novel direction for personalized phytotherapy. Systematic Review Registration: Identifier CRD42024514198.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.