ArticleTranslational cancer research2025
Integration analysis of single-cell transcriptome reveals SPP1
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Phagocytic remodeling in CD74Translational cancer research · 2026Article
- Tumor-Promoting Crosstalk of MMP11⁺ Fibroblasts and SPP1⁺ Macrophages Drive Poor Prognosis in Breast Cancer: Integrated Multi-Omics Analysis.ImmunoTargets and therapy · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The death of lung cancer patients is closely linked to brain metastasis. While tumor-associated macrophages (TAMs) have been extensively studied in the context of lung cancer metastasis, their role and mechanism in brain metastasis remain unclear. In this study, we analyzed and explored the heterogeneity and differential gene expression of TAM subsets associated with brain metastasis of lung cancer using single-cell transcriptome data. Methods: Single-cell RNA sequencing datasets related to brain metastasis of lung cancer were acquired from the Gene Expression Omnibus (GEO) database and ArrayExpress platform. Through standard single-cell data analysis and visualization, we investigated the differential gene expression and signal pathway enrichment of macrophage subsets associated with brain metastasis of lung cancer, focusing on the unique microenvironment and cell component differences in brain metastasis tissues. Results: Compared with normal lung tissue, brain tissue, and tumor focus of primary lung cancer, we observed a significant up-regulation in the cell proportions of SPP1 Conclusions: Our findings demonstrate the close association of SPP1
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