Evidence map›Paper›PMID 41158480›Full record

ArticleERJ open research2025

Gene expression profiling of airway epithelium in

Koji Furuuchi, Minako Hijikata, Shintaro Seto, Akiko Miyabayashi, Keiko Wakabayashi, Takayuki Nakagawa, Tsutomu Yoshida, Kiyomi Shimoda, Miyako Hiramatsu, Yuji Shiraishi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Koji FuruuchiDepartment of Pathophysiology and Host Defense, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Minako HijikataDepartment of Pathophysiology and Host Defense, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Shintaro SetoDepartment of Pathophysiology and Host Defense, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Akiko MiyabayashiDepartment of Pathophysiology and Host Defense, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Keiko WakabayashiDepartment of Pathophysiology and Host Defense, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Takayuki NakagawaDepartment of Thoracic Surgery, National Hospital Organization Ibarakihigashi National Hospital, Ibaraki, Japan.
Tsutomu YoshidaDepartment of Thoracic Surgery, Showa University Fujigaoka Hospital, Kanagawa, Japan.
Kiyomi ShimodaRespiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Miyako HiramatsuRespiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Yuji ShiraishiRespiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Kozo MorimotoRespiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.ORCID https://orcid.org/0000-0002-8239-9275
Naoto KeichoThe Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Impaired mucociliary clearance is associated with nontuberculous mycobacterial lung disease (NTM-LD). While airway epithelial cells (AECs), which are essential for maintaining this defence mechanism, play a central role in NTM-LD pathogenesis, their Methods: We profiled gene expression of AECs from surgical specimens of age-matched female MAC-LD patients (n=7) and lung cancer patients (n=8), the latter serving as noninfectious controls. Differentially expressed genes identified through weighted gene coexpression network analysis were validated using quantitative reverse transcriptase PCR (qRT‒PCR) in an independent cohort (MAC-LD: n=19, Lung cancer: n=25). Associations between AEC gene expression and MAC-LD clinical phenotypes were also investigated. Results: We identified 54 upregulated and 4 downregulated genes in AECs from MAC-LD patients. In addition to immune-related genes enriched in antigen presentation, complement and coagulation cascades, neutrophil migration and the interleukin-17 signalling pathway, Conclusions:

Identifiers

PMID41158480
PMCPMC12557404

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.