ReviewERJ open research2025
Natural killer T-cells in asthma pathogenesis and treatment: old problems and future perspectives.
Review in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer T-cells (NKT-cells) are immunological cells expressing features of both innate and adaptive immunity, which have been reported to be involved in the pathogenesis of asthma and in the induction of airway hyperresponsiveness (AHR). In this review we discuss the controversial results obtained in the past due to the lack of standardised analytical methods and the inhomogeneity of cohorts. In recent years, the availability of more advanced techniques led to a significant improvement in the phenotyping of these cells. Several research studies, both in mice and humans, reported that NKT-cells might be involved in the induction of AHR through the secretion of cytokines. In mouse models, in the absence of NKT-cells, AHR was not triggered and the airway eosinophil count was reduced. A relationship between NKT-cells and both innate (
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.