ArticleJournal of oral biology and craniofacial research
Modulating cortical excitability through transcranial direct current stimulation combined with therapeutic exercise for craniofacial myofascial pain: Randomized controlled trial.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Temporomandibular dysfunction (TMD) involves pain, motor impairment and psychological distress, often sustained by maladaptive central neuroplasticity. Transcranial direct current stimulation (tDCS) can modulate cortical excitability, enhance descending inhibitory control, and improve function, making it a promising adjunct to multimodal rehabilitation. Objective: To examine the effects of tDCS combined with multimodal rehabilitation on pain, motor performance and psychosocial outcomes in TMD and to explore associated neurophysiological mechanism. Methods: In this randomized, assessor-blinded trial, participants received either active tDCS plus rehabilitation or Sham tDCS plus rehabilitation. Assessments occurred at baseline, post-intervention (8 weeks) and at 3 and 6-month follow-up. Primary outcomes were EEG Alpha Modulation Index (AMI), Pressure pain threshold (PPT) and Jaw functional limitation scale (JFLS); secondary outcomes included neck disability index (NDI), patient global impression of change (PGIC) data were analyzed via repeated-measures ANOVA with intention-to-treat principles. Results: Active tDCS with rehabilitation produced greater improvements than sham in all outcomes (p < 0.001). EEG Alpha Modulation Index increased ( Conclusion: tDCS combined with therapeutic exercise safely enhances cortical excitability, pain modulation, function and patient outcomes in TMD, supporting Multimodal rehabilitation. Further research should refine protocals and confirm long-term benefits across populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.