Evidence map›Paper›PMID 41158623›Full record

ArticleFrontiers in endocrinology2025

Effects of drospirenone and ethinylestradiol tablets (II) combined with metformin on the composition of gut microbiota in polycystic ovary syndrome with insulin resistance.

Yanglu Liu, Qingmei Wang, Lingling Han, Xue Shao, Xin Wang, Xin Liu, Jiayi Wang, Shuang Luo, Baiyu Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanglu LiuDepartment of Obstetrics and Gynecology, Suining Central Hospital, Suinig, Sichuan, China.
Qingmei WangSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Lingling HanSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Xue ShaoSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Xin WangSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Xin LiuSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Jiayi WangSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Shuang LuoDepartment of Obstetrics and Gynecology, Suining Central Hospital, Suinig, Sichuan, China.
Baiyu LuDepartment of Obstetrics and Gynecology, Suining Central Hospital, Suinig, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To explore the relationship between polycystic ovary syndrome with insulin resistance (PCOS-IR) and gut microbiota by analyzing the composition characteristics of gut microbiota in PCOS without or with Insulin resistance (IR) and the changes before and after treatment. Methods: Women with PCOS were recruited and divided into polycystic ovary syndrome without insulin resistance (PCOS-NIR) group and PCOS-IR group. The PCOS-NIR group was given oral drospirenone and ethinylestradiol tablets (II), and the PCOS-IR group was given oral drospirenone and ethinylestradiol tablets (II) combined with metformin hydrochloride tablets. The course of treatment was 3 months. Baseline data, blood and stool samples were collected before and after treatment. All those stool samples were used for 16S rDNA sequencing to analyze the composition of gut microbiota in each group and their correlation with biochemical parameters. Results: 1. Baseline data and biochemical parameters: before treatment, body mass index (BMI) in PCOS-NIR group was less than that in PCOS-IR group( Conclusion: 1. There is a difference in the relative abundance of

Indexed as

AndrostenesEthinyl EstradiolGastrointestinal MicrobiomeInsulin ResistanceMetforminPolycystic Ovary SyndromeAdultDrug CombinationsDrug Therapy, CombinationFemaleHumansHypoglycemic AgentsTabletsYoung AdultAndrostenesdrospirenonedrospirenone and ethinyl estradiol combinationDrug CombinationsEthinyl EstradiolHypoglycemic AgentsMetforminTablets16S rDNAdrospirenone and ethinylestradiol tablets (II)gut microbiotainsulin resistancemetforminpcos

Identifiers

PMID41158623
PMCPMC12554447

What Socratic holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.