Evidence map›Paper›PMID 41158648›Full record

ArticleFrontiers in nutrition2025

Clinical practice insight: vasoactive-inotropic drugs do not impede early enteral nutrition in pediatric ECMO support.

Ye Ren, Run Zhou, Hongxing Dang, Yueqiang Fu, Chengjun Liu, Jing Li

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ye Ren *Ministry of Education Key Laboratory of Child Development and Disorders, Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing, China.
Run Zhou *Ministry of Education Key Laboratory of Child Development and Disorders, Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing, China.
Hongxing DangMinistry of Education Key Laboratory of Child Development and Disorders, Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing, China.
Yueqiang FuMinistry of Education Key Laboratory of Child Development and Disorders, Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing, China.
Chengjun LiuMinistry of Education Key Laboratory of Child Development and Disorders, Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing, China.
Jing LiMinistry of Education Key Laboratory of Child Development and Disorders, Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate whether vasoactive-inotropic drug use impedes the early initiation of enteral nutrition (EN) and affects energy intake adequacy in pediatric patients receiving extracorporeal membrane oxygenation (ECMO) support. Methods: A prospective observational cohort study was conducted among pediatric ECMO patients between June 2018 and June 2024. Patients were categorized into early (≤ 48 h) and delayed (> 48 h) EN initiation groups, and into energy-deficient (< 30% of energy target) and non-deficient (≥ 30%) groups based on daily EN energy intake during the first five ECMO days. Vasoactive-Inotropic Score (VIS), PRISM III score, EN interruptions, and energy intake adequacy were analyzed. Spearman correlation and Cohen's d were used to explore associations between VIS and EN intake. A support vector machine (SVM) model was used to identify predictors of energy intake status. Results: A total of 64 patients were included, with 43 (67.2%) receiving EN within 48 h. VIS did not significantly differ between early and delayed EN groups. Delayed EN was associated with higher PRISM III scores ( Conclusion: Vasoactive-inotropic drug use does not impede the early initiation of EN in pediatric ECMO patients. However, higher VIS in the initial 48 h is associated with suboptimal energy delivery. These findings suggest that while EN can be started early despite vasoactive support, closer monitoring of hemodynamic status is warranted to optimize nutritional adequacy.

Indexed as

early enteral nutritionenergy intake adequacyextracorporeal membrane oxygenationpediatricsvasoactive-inotropic drugs

Identifiers

PMID41158648
PMCPMC12557776

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.