ArticleInternational journal of general medicine2025
Association of Systemic Inflammation Indexes with 90-Day Functional Outcomes in Acute Ischemic Stroke Patients Undergoing Intravenous Thrombolysis.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Intravenous Thrombolysis Preceding Mechanical Thrombectomy in Patients with Acute Ischemic Stroke Reduces the Inflammatory Response: Preliminary Results Based on Retrospective Analysis of Medical Documentation.Journal of clinical medicine · 2026Article
- Human lncRNA, hLinfRNA7 (IDO1-AS) Regulates Cytokine Expression, Tryptophan Catabolism, and Inflammatory Response in Macrophage.Molecular and cellular biology · 2026Article
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4 authors.
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Abstract
Background and Purpose: The neutrophil-to-lymphocyte ratio (NLR) is a well-established inflammatory marker, while newer indices such as the systemic inflammation response index (SIRI), inflammation prognostic index (IPI), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV) provide broader insights into systemic inflammation and immune status. This study evaluated the association between these composite indices, their dynamic changes after intravenous thrombolysis, and 90-day outcomes in acute ischemic stroke (AIS). Methods: We retrospectively included AIS patients treated with intravenous rt-PA within 4.5 hours at Leshan People's Hospital and Qianwei County People's Hospital (September 2021-January 2025). Hematological parameters at admission and day 7 were used to calculate NLR, SIRI, SII, IPI, and PIV. Outcomes were assessed by the modified Rankin Scale (mRS) at 3 months, categorized as favorable (mRS 0-2) vs unfavorable (mRS 3-6), or survival (mRS 0-5) vs death (mRS 6). Multivariable logistic regression and receiver operating characteristic (ROC) analyses were performed. Results: Among 269 patients, inflammatory indices showed distinct patterns across groups. SII, SIRI, PIV, and IPI increased in patients with unfavorable outcomes or death but decreased in those with favorable outcomes or survival. T2 values and relative changes (FC) were significantly associated with outcomes. In adjusted models, IPI, SIRI, and PIV at T2 and their dynamic changes remained independent predictors, while SII was significant for unfavorable outcomes but marginal for mortality (P = 0.072). ROC analysis showed moderate discrimination (AUC > 0.6), with IPI and SIRI demonstrating the best predictive value. Conclusion: Dynamic changes in composite inflammatory indices after thrombolysis are closely associated with 3-month outcomes in AIS. As simple and reproducible markers derived from routine blood tests, these indices may aid short-term risk stratification and individualized management.
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