SynthesisJournal of cosmetic dermatology2025
Efficacy of Cosmetic Debridement and Suture With Recombinant Human EGF in Maxillofacial Trauma: A Meta-Analysis.
Synthesis in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Cosmetic Debridement and Suture With Recombinant Human EGF in Maxillofacial Trauma: A Meta-Analysis.Journal of cosmetic dermatology · 2025Pooled it
- Comment on "Efficacy of Cosmetic Debridement and Suture With Recombinant Human EGF in Maxillofacial Trauma: A Meta-Analysis".Journal of cosmetic dermatology · 2025Article
- Synergistic effects of platelet-rich fibrin and CTLA4Ig gene-transfected porcine skin on accelerating wound healing in a rat model of deep second-degree burns: a mechanistic study.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze and evaluate the clinical effect of cosmetic debridement and suture combined with recombinant human epidermal growth factor (rhEGF).
methodsA systematic review of the literature was performed by searching China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP Chinese Science and Technology Journals, China Biomedicine, PubMed, Web of Science, and Cochrane Library. RevMan 5.4.1 software was used for statistical analysis. Heterogeneity among studies was assessed using the Q test (p value). Publication bias was evaluated via funnel plots, forest plots were generated, and the combined odds ratio (OR) was calculated using a fixed-effects model or random-effects model.
resultsThe combined therapy showed favorable clinical efficacy [OR = 6.62, 95% confidence interval (95% CI) (3.14-13.92), p < 0.00001], shorter wound healing time [mean difference (MD) = -2.69, 95% CI (-3.10 to -2.29), p < 0.00001], and improved scar outcomes (lower Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS) scores) at 6 months. Serum epidermal growth factor (EGF) levels were higher, while interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were lower in the combined therapy group (all p < 0.05).
conclusionAesthetic debridement and suture combined with rhEGF have a good clinical effect in the treatment of maxillofacial trauma.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.