Evidence map›Paper›PMID 41159325›Full record

ArticleHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology2025

[Aloe-emodin inhibits scar tissue fibrosis through thrombospondin-1-PI3k-Akt pathway].

Hongbao Geng, Xingyi Zhang, Siwei Zhou, Na Li, Jia Liu, Xuewei Yuan, Chunliu Ning, Xudong Zhang, Wei Huang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongbao GengDept. of Stomatology, Women and Children's Health Hospital in Shijiazhuang, Shijiazhuang 050000, China.
Xingyi ZhangHebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Disease, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, China.
Siwei ZhouDept. of Stomatology, Shijiazhuang Fourth Hospital, Shijiazhuang 050011, China.
Na LiDept. of Stomatology, Shijiazhuang Second Hospital, Shijiazhuang 050051, China.
Jia LiuDept. of Stomatology, Shijiazhuang Second Hospital, Shijiazhuang 050051, China.
Xuewei YuanDept. of Stomatology, Shijiazhuang Second Hospital, Shijiazhuang 050051, China.
Chunliu NingHebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Disease, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, China.
Xudong ZhangHebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Disease, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, China.
Wei HuangHebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Disease, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo propose a hypothesis that aloe-emodin may inhibit scar tissue fibrosis through thrombospondin-1(THBS1)-PI3K-Akt pathway.

methodsBy cultivating fibroblasts derived from scar tissue after cleft palate surgery in humans, aloe emodin of different concentrations (10, 20, 30, 40 and 50 μmol/L) was added to the cells which activity was detected. At the same time, transcriptome sequencing was performed on scar tissue and cells, and bioinformatics methods were used to explore potential targets and signaling pathways of scar tissue fibrosis.

resultsAloe-emodin had a concentration dependent inhibitory effect on fibroblast proliferation,with the 40 μmol/L concentration group showing the most significant effect. The results of tissue and cell sequencing indicated that differentially expressed genes were significantly enriched in extracellular matrix-receptor interaction pathway, and shared a common differential gene which was THBS1. The ORA analysis results indicated that differentially expressed genes, including THBS1, were significantly enriched in the PI3K-Akt signaling pathway.

conclusionsAloe emodin may inhibit the PI3K-Akt pathway by downregulating THBS1, thereby reducing the proliferation activity of fibroblasts derived from postoperative palatal scar tissue.

Indexed as

AnthraquinonesCicatrixPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionThrombospondin 1Cell ProliferationCells, CulturedFibroblastsFibrosisHumansaloe emodinAnthraquinonesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktThrombospondin 1thrombospondin-1, humanaloe-emodinfibrosispalatal scarPI3K-Akt signaling pathwaythrombospondin-1

Identifiers

PMID41159325
PMCPMC12573707

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.