SynthesisVeterinary research communications2025
Prevalence and mechanisms of antimicrobial resistance in respiratory bacterial pathogens of ruminants: a systematic review.
Synthesis in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Antimicrobial resistance (AMR) in respiratory pathogens of ruminants is a growing threat to animal health, veterinary treatment efficacy, and food production. However, consolidated global data on the prevalence and molecular mechanisms of AMR in these pathogens remain limited, particularly across diverse regions and livestock systems. This systematic review aimed to evaluate the prevalence and molecular mechanisms of AMR in bacterial pathogens responsible for respiratory infections in ruminants. A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was conducted to identify English-language, peer-reviewed articles published between January 1, 2020, and May 31, 2025. Eligible studies reported on AMR prevalence and/or mechanisms in respiratory pathogens isolated from cattle, sheep, goats, and buffaloes. Study screening, data extraction, and quality appraisal were performed according to PRISMA guidelines, using the Joanna Briggs Institute (JBI) checklist. Fifty studies met the inclusion criteria, covering bacterial isolates from Africa, Asia, Europe, the Americas, and Oceania. Resistance prevalence ranged from 0.8% to 100%, with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis being the most frequently reported pathogens. Resistance was most common against tetracyclines, macrolides, sulfonamides, and β-lactams. Identified mechanisms included β-lactamase production, such as blaROB-1, blaTEM, efflux pumps msr(E), tet(H), target-site mutations gyrA, parC, 23 S rRNA, and horizontal gene transfer via plasmids and integrative and conjugative elements. This review underscores the global burden of AMR and multidrug resistance in ruminant respiratory pathogens and their potential zoonotic implications. Strengthening molecular surveillance, harmonising diagnostic standards, and integrating antimicrobial usage data, especially in underrepresented regions such as Southeast Asia, are essential to inform targeted interventions.
Indexed as
Identifiers
41160243What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.