Evidence map›Paper›PMID 41160688›Full record

ArticleScience advances2025

Dynamic human admixture histories over the past ~1300 years at the northern Himalayan frontier.

Esha Bandyopadhyay, David Witonsky, Constanza de la Fuente Castro, Nagarjuna Pasupuleti, Jose A Urban Aragon, Juhyeon Lee, Vivaswat Shastry, Nathan Sander, Bhavna Ahlawat, Aparna Dwivedi and 22 more

Abstract readHistorical Article
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Esha BandyopadhyayDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-8080-2825
David WitonskyDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
Constanza de la Fuente CastroDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-2857-3615
Nagarjuna PasupuletiBirbal Sahni Institute of Palaeosciences, Lucknow, Uttar Pradesh 226007, India.ORCID 0000-0002-1886-4400
Jose A Urban AragonDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-2350-2244
Juhyeon LeeSchool of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0001-7008-4471
Vivaswat ShastryCommittee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-7294-5607
Nathan SanderDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
Bhavna AhlawatBirbal Sahni Institute of Palaeosciences, Lucknow, Uttar Pradesh 226007, India.ORCID 0000-0003-2095-0532
Aparna DwivediBirbal Sahni Institute of Palaeosciences, Lucknow, Uttar Pradesh 226007, India.ORCID 0009-0004-6267-9810
Tanzin AngmoRock Art and Historical Society of Spiti, Himachal Pradesh 172114, Kaza, India.
Aman SharmaShoolini University, Chitrakoot School of Liberal Arts, Himachal Pradesh 173229, Solan, India.ORCID 0009-0001-6986-745X
Amit KaushikChaudhary Charan Singh Haryana Agricultural University, Hisar, Haryana 125004, India.ORCID 0000-0001-8742-5404
Hannah Marie MootsDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-6637-6321
J Víctor Moreno-MayarGlobe Institute, Faculty of Health and Medical Science, University of Copenhagen, 1350 Copenhagen, Denmark.ORCID 0000-0002-7712-4496
Sachin KumarBirbal Sahni Institute of Palaeosciences, Lucknow, Uttar Pradesh 226007, India.ORCID 0000-0002-5249-305X
Rakesh Chandra BhattDepartment of History and Archaeology, Hemwati Nandan Bahuguna Garhwal University, Srinagar, Uttarakhand 246174, India.ORCID 0000-0002-5738-1487
Kavita Bist MengwalArchaeological Survey of India, Dehradun Circle, Dehradun, Uttarakhand 248001, India.ORCID 0009-0008-0492-1292
Hari ChauhanHimachal State Museum, Shimla, Himachal Pradesh 171004, India.
Rajinder K GanjooDepartment of Geology, University of Jammu, Jammu 180006, India.ORCID 0000-0001-6256-2314
Veena Mushrif-TripathyDepartment of AIHC and Archaeology, Deccan College Post Graduate and Research Institute, Pune, Maharashtra 411006, India.
Simadri Bihari OtaArchaeological Survey of India, Regional Director, Central Region, Bhopal, Madhya Pradesh 462011, India.
Christina WarinnerDepartment of Anthropology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-4528-5877
Mark AldenderferDepartment of Anthropology and Heritage Studies, University of California, Merced, CA 95343, USA.ORCID 0000-0002-7033-4319
Anna Di RienzoDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-8982-9098
Choongwon JeongSchool of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0003-3049-2352
Nagendra Singh RawatDepartment of History and Archaeology, Hemwati Nandan Bahuguna Garhwal University, Srinagar, Uttarakhand 246174, India.ORCID 0000-0001-7833-0382
Tsering NorbuRock Art and Historical Society of Spiti, Himachal Pradesh 172114, Kaza, India.
Ekta SinghShoolini University, Chitrakoot School of Liberal Arts, Himachal Pradesh 173229, Solan, India.ORCID 0000-0002-5572-2524
Vinod NautiyalDepartment of History and Archaeology, Hemwati Nandan Bahuguna Garhwal University, Srinagar, Uttarakhand 246174, India.
Maanasa RaghavanDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-1997-0739
Niraj RaiBirbal Sahni Institute of Palaeosciences, Lucknow, Uttar Pradesh 226007, India.ORCID 0000-0002-1251-9390

Funding

Genetic adaptations to high altitudeR01HL119577 · NHLBI · UNIVERSITY OF CHICAGO · PI DI RIENZO, ANNA · 2014 to 2023
$4.9M
Reconstructing the evolutionary history of humans and human-associated microbes in South Asia using an integrated genomics approachR35GM143094 · NIGMS · UNIVERSITY OF CHICAGO · PI RAGHAVAN, MAANASA · 2021 to 2025
$2.0M
NHLBI NIH HHS R01 HL119577NIGMS NIH HHS R35 GM143094
6 · The paper itself

Abstract

Archaeological and paleogenomic evidence from the Tibetan Plateau and high-altitude Central Himalayas suggest biocultural connections with each other and with lowland East, Central, and South Asia. However, genetic histories at the northern frontier of the Indian Himalayas, which is geographically more proximal to Central and lowland South Asia, remain underexplored. We analyzed genome-wide data from 7 ancient (~2300 to 100 years old) and 10 present-day individuals from the northern Indian Himalayas and one ~3370-year-old individual from the Central Himalayas in Nepal. Ancient and present-day individuals from the northern Himalayas predominantly have Tibetan-related genetic ancestry, likely the source of high-altitude adaptive variants in these individuals, with substantial Steppe-related genetic ancestry that is observed in all individuals dating between ~1300 years and present day. In addition, some present-day individuals have lowland South Asian admixture. Our analyses reveal a dynamic interplay between genetic admixture and continuity in the northern Himalayas.

Indexed as

Asian PeopleGenetics, PopulationAltitudeArchaeologyGenome, HumanHistory, AncientHumansNepal

Identifiers

PMID41160688
PMCPMC12571065

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.