ArticleThe Journal of clinical endocrinology and metabolism2026
Diurnal Light Exposure and Rest-Activity Rhythms in Relation to MASLD: Insights From 2 Nationwide Cohort Studies.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Non-pharmacological treatment of MASLD.Diabetologia · 2026Review
- Sympathetic activation links light exposure and rest-activity rhythm to liver injury and bile acid dysregulation.Npj biological timing and sleep · 2026Article
- Circadian and behavioral timing in MASLD: a systematic review of human observational studies.EClinicalMedicine · 2026Article
- Review
- Diurnal Light Exposure and Rest-Activity Rhythms in Relation to MASLD: Insights From 2 Nationwide Cohort Studies.The Journal of clinical endocrinology and metabolism · 2026Article
- Rest-activity rhythms and cardiovascular events in cardiovascular-kidney-metabolic syndrome: evidence from two nationwide cohorts.American journal of preventive cardiology · 2026Article
- Morphofunctional State of the Liver Under Conditions of Three-Month Dark Deprivation: The Influence of Circadian Disruptions and Melatonin.International journal of molecular sciences · 2026Article
- Interplay between circadian rhythms, gut microbiota, and MASLD: from mechanistic foundations to therapeutic opportunities.Frontiers in medicine · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
contextCircadian rhythms may influence metabolic dysfunction-associated steatotic liver disease (MASLD), but the effect of personal light exposure and rest-activity rhythms on MASLD risk remain unclear.
objectiveTo examine the associations between 24-hour light exposure, rest-activity rhythm (24-h-RAR), and the risk of incident MASLD, as well as how these factors influence genetic risk and life expectancy in individuals with MASLD.
methodsThis study used accelerometry data from both the National Health and Nutrition Examination Survey (NHANES) and UK Biobank cohorts. 24 h-RAR was assessed using nonparametric metrics, including activity level during the most active 10 hours (M10), activity level during the least active 5 hours (L5), relative amplitude (RA), M10 onset, and L5 onset. Light exposure was categorized into daytime and nighttime periods, with exposure durations recorded separately at different threshold levels. The primary outcome was MASLD, with secondary outcomes including fibrosis and cirrhosis.
resultsIn the UK Biobank prospective analysis, each 0.1-unit and 1-unit increase in RA and M10 were associated with a 30% and 2% reduction of MASLD risk, respectively. In contrast, each 1-unit increase in L5 and delayed L5 onset were linked to an 8% and 21% increase of MASLD risk. Moreover, each additional hour of daylight exposure above 6000 lux was associated with a 9% lower risk of MASLD, while each additional 30 minutes of nocturnal light exposure above 30 lux corresponded to a 22% higher risk of MASLD. Additionally, a favorable 24 h-RAR profile and adequate light exposure were associated with a lower risk of fibrosis and cirrhosis, as well as improved life expectancy among participants with MASLD. Similar associations were observed in the NHANES analysis.
conclusionGreater daytime light exposure, reduced nocturnal light exposure, and regulated RARs may protect against MASLD and prevent its progression to liver fibrosis and advanced liver disease.
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