Evidence map›Paper›PMID 41160737›Full record

ArticleCell reports2025

Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity.

Teresa M Lamb, Kathrina D Castillo, Rachel Porter, Cheng Wu, Samuel O Purvine, Griffin Best, Erika Zink, Ebimobowei O Preh, Lunda Shen, Matthew S Sachs and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Teresa M LambCenter for Biological Clocks Research, Texas A&M University, College Station, TX 77843, USA; Department of Biology, Texas A&M University, College Station, TX 77843, USA.
Kathrina D CastilloCenter for Biological Clocks Research, Texas A&M University, College Station, TX 77843, USA; Department of Biology, Texas A&M University, College Station, TX 77843, USA.
Rachel PorterCenter for Biological Clocks Research, Texas A&M University, College Station, TX 77843, USA; Department of Biology, Texas A&M University, College Station, TX 77843, USA.
Cheng WuDepartment of Biology, Texas A&M University, College Station, TX 77843, USA.
Samuel O PurvineEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, 902 Battelle Blvd., Richland, WA 99352, USA; Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, 902 Battelle Blvd., Richland, WA 99352, USA.
Griffin BestCenter for Biological Clocks Research, Texas A&M University, College Station, TX 77843, USA; Department of Biology, Texas A&M University, College Station, TX 77843, USA.
Erika ZinkEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, 902 Battelle Blvd., Richland, WA 99352, USA; Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, 902 Battelle Blvd., Richland, WA 99352, USA.
Ebimobowei O PrehCenter for Biological Clocks Research, Texas A&M University, College Station, TX 77843, USA; Department of Biology, Texas A&M University, College Station, TX 77843, USA.
Lunda ShenDepartment of Biology, Texas A&M University, College Station, TX 77843, USA.
Matthew S SachsDepartment of Biology, Texas A&M University, College Station, TX 77843, USA.
Deborah Bell-PedersenCenter for Biological Clocks Research, Texas A&M University, College Station, TX 77843, USA; Department of Biology, Texas A&M University, College Station, TX 77843, USA. Electronic address: dpedersen@tamu.edu.

Funding

Mechanisms of Circadian Clock Control of mRNA TranslationR35GM126966 · NIGMS · TEXAS A&M UNIVERSITY · PI Deborah Bell-Pedersen · 2018 to 2026
$6.6M
NIGMS NIH HHS R35 GM126966
6 · The paper itself

Abstract

Ribosome composition is dynamic, shifting with cell state and stress, but whether it varies with circadian time is unknown. Here, we uncover circadian clock-driven changes in ribosome composition in Neurospora crassa. Mass spectrometry of ribosomes across circadian time identified six ribosomal proteins and one associated factor under clock control. Rhythms in eL31 abundance were validated in purified ribosomes, and deletion of el31 disrupted translation rhythms in nearly half of rhythmically translated mRNAs. N. crassa eL31 promotes circadian control of translation termination and impacts elongation fidelity while maintaining Mg homeostasis, a key determinant of translational accuracy. These findings reveal that the circadian clock reprograms ribosome composition to orchestrate rhythmic translation and fidelity, temporally expanding the proteome beyond the static genome to align cellular function with time of day.

Indexed as

Circadian ClocksNeurospora crassaProtein BiosynthesisRibosomesCircadian RhythmFungal ProteinsRibosomal ProteinsRNA, MessengerFungal ProteinsRibosomal ProteinsRNA, Messengercircadian clockCP: Molecular biologyeL31magnesium ion homeostasisribosome compositiontranslationtranslation fidelityZuotin

Identifiers

PMID41160737
PMCPMC12790415

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.