GLP-1 receptor agonists × glycemic control

TrialBMJ open diabetes research & care2025

Using real-world data to predict findings of an ongoing phase IV trial: glycemic control of semaglutide versus standard of care.

Sushama Kattinakere Sreedhara et al.PubMed ↗Full text ↗Publisher ↗

  • Injectable semaglutidelooks bad hereHigher achieving glycemic control.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Injectable semaglutide went with higher achieving glycemic control

+30%+16% to +45%

injectable semaglutide vs SoC medications (dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter-2 inhibitors, SUs, or glucagon-like peptide-1 agonists)

Bigger than 2 in 10 for glycemic control

As reported

RR 1.30, 95% CI 1.16–1.45

Who was studied, and how

2,316people in the Prediction of the SEPRA Diabetes Trial in Healthcare Claims Data trial, from 2021
of them with type 2 diabetes, in this paper

Already taking injectable semaglutide, or nottheir own situation, not assigned

on injectable semaglutide
SoC medications (dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter-2 inhibitors, SUs, or glucagon-like peptide-1 agonists)

Injectable semaglutide went with higher achieving glycemic control+30%

correlation, not a test

the abstract, start to end

were 30% (risk ratio (95% CI), 1.30 (1.16 to 1.45)) more likely to

← favours treatmentfavours comparator →
could be chance
Achieving glycemic control (A1C <7%)injectable semaglutide vs SoC medications (dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter-2 inhibitors, SUs, or glucagon-like peptide-1 agonists)
RR 1.301.16–1.45
GLP-1 receptor agonistsGlycemic control
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Not cited yet

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 41161770