Evidence map›Paper›PMID 41162154›Full record

ArticleGenes & development2026

Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex.

Adebanjo Adedoja, Niclole Stuhr, Yifei Zhou, Yuyao Zhang, Armen Yerevanian, Alexander A Soukas

Abstract read
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adebanjo AdedojaDepartment of Medicine, Diabetes Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Niclole StuhrDepartment of Medicine, Diabetes Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Yifei ZhouDepartment of Medicine, Diabetes Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Yuyao ZhangDepartment of Medicine, Diabetes Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Armen YerevanianDepartment of Medicine, Diabetes Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; asoukas@mgh.harvard.edu ayerevanian@partners.org.
Alexander A SoukasDepartment of Medicine, Diabetes Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; asoukas@mgh.harvard.edu ayerevanian@partners.org.ORCID 0000-0002-9100-2436

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria play a crucial role in cellular energy metabolism and homeostasis and are strongly implicated in aging and age-related diseases. The outer mitochondrial membrane protein voltage-dependent anion channel (VDAC) plays multiple roles in mitochondrial homeostasis, including transport of metabolites, ATP, and Ca

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsLongevityMitochondriaUnfolded Protein ResponseAnimalsVoltage-Dependent Anion Channel 1Caenorhabditis elegans ProteinsVoltage-Dependent Anion Channel 1mitochondriamito-stressmitoUPRPeBoW

Identifiers

PMID41162154
PMCPMC12758134

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.