Evidence map›Paper›PMID 41162846›Full record

ArticleBMC plant biology2025

Dual roles of SmCLE25 peptide in regulating stresses response and leaf senescence.

Wei Zhao, Yuna Sun, Jingjing Li, Yinan Wu, Yangli Tian, Junwei Wei, Yinshuai Tian

Abstract read
In one paragraph

Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei ZhaoSchool of Medicine, Hebei University of Engineering, Handan, Hebei Province, 056038, China.
Yuna SunSchool of Medicine, Hebei University of Engineering, Handan, Hebei Province, 056038, China.
Jingjing LiSchool of Medicine, Hebei University of Engineering, Handan, Hebei Province, 056038, China.
Yinan WuSchool of Medicine, Hebei University of Engineering, Handan, Hebei Province, 056038, China.
Yangli TianSchool of Medicine, Hebei University of Engineering, Handan, Hebei Province, 056038, China.
Junwei WeiSchool of Medicine, Hebei University of Engineering, Handan, Hebei Province, 056038, China.
Yinshuai TianSchool of Landscape and Ecological Engineering, Hebei University of Engineering, Handan, Hebei Province, 056038, China. tianyinshuai@hebeu.edu.cn.

Funding

This work was supported by Science Research Project of Hebei Education Department QN2025412
6 · The paper itself

Abstract

Peptide hormones play crucial roles as signaling regulators in plant development and environmental adaptation. This study identified the Salvia miltiorrhiza CLE peptide SmCLE25, which is involved in regulating leaf senescence and multiple stress responses. SmCLE25 transcription is upregulated by ABA, JA, high salinity, and drought stresses. Application of synthetic SmCLE25 mature peptide significantly enhanced S. miltiorrhiza resistance to salt and drought tolerance. Overexpression of SmCLE25 in Arabidopsis thaliana delayed senescence and enhanced drought resistance. Seed germination assays demonstrated that elevated SmCLE25 expression enhanced germination efficiency under salt and drought conditions. Mechanistic analysis revealed that SmCLE25 peptide reduces reactive oxygen species (ROS) accumulation under stress by downregulating ROS biosynthesis-related genes RbohC and RbohE. This study provides novel insights into the regulatory mechanisms of peptide signaling in leaf senescence and stress adaptation to salinity and drought.

Indexed as

ArabidopsisPlant LeavesPlant ProteinsPlant SenescenceSalviaStress, PhysiologicalDroughtsGene Expression Regulation, PlantGerminationPlants, Genetically ModifiedReactive Oxygen SpeciesPlant ProteinsReactive Oxygen SpeciesLeaf senescenceROSSmCLE25S. miltiorrhizaStress response

Identifiers

PMID41162846
PMCPMC12574093

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.