ArticleBMC genomics2025
Genome-wide identification and multi-level analysis of the HSP gene superfamily in Aphidoletes aphidimyza: sHSP gene family expansion and its role in diapause regulation.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundInsect diapause is a critical adaptive strategy for surviving unfavorable environmental conditions. The predatory insect Aphidoletes aphidimyza, widely used in biological pest control, relies on diapause for commercial storage and application. Heat shock proteins (HSPs), particularly small HSPs (sHSPs), are known to play pivotal roles in stress tolerance and protein homeostasis maintenance during diapause. However, the regulatory mechanisms of the HSP gene superfamily, especially the sHSP gene family, in A.aphidimyza diapause remain poorly understood. This study aims to comprehensively analyze the HSP gene superfamily in A.aphidimyza and elucidate the functional and regulatory roles of sHSPs in diapause.
resultsOur findings reveal that A.aphidimyza has evolved a multi-layered regulatory mechanism through selective expansion of the sHSP gene family. At the transcriptional level, specific transcription factors such as Ftzf1 bind to sHSP gene promoters, enhancing their expression during diapause. Post-transcriptionally, Among the 34 members of the sHSP gene family, 32 have only one exon, the intronless, single-exon structure of sHSP genes facilitates rapid mRNA maturation, enabling swift protein synthesis. Post-translational modifications, such as phosphorylation, regulate the oligomeric state of sHSP proteins, allowing them to dissociate into functional dimers and protect cellular protein homeostasis under stress. Notably, a unique branch of the sHSP gene family (CladeX) exhibited expansion, higher expression during diapause, relatively conserved sequences, suggesting its critical role in environmental adaptation.
conclusionsThis study provides a comprehensive analysis of the A.aphidimyza HSP gene superfamily, highlighting the pivotal role of the sHSP gene family, particularly CladeX, in diapause regulation. The multi-level regulatory mechanisms-transcriptional, post-transcriptional, and post-translational-enable A.aphidimyza to rapidly respond to adverse conditions like low temperature and short photoperiod, ensuring survival triggering diapause. These insights not only deepen our understanding of insect diapause but also offer potential applications for improving the storage and commercial use of A.aphidimyza as a biological control agent.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.