ArticleCardiovascular diabetology2025
Associations between triglyceride-glucose-related indices and all-cause and cardiovascular mortality among individuals with atrial fibrillation and metabolic syndrome: a cohort study of the UK biobank.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- The triglyceride-glucose index modulates the association between diabetes duration and insulin resistance in type 2 diabetes: a large cross-sectional study.Frontiers in endocrinology · 2026Trial
- Associations between prediabetes, type 2 diabetes and incident atrial fibrillation in patients with hypertension: Results from the Swedish Primary Care Cardiovascular Database.American journal of preventive cardiology · 2026Article
- The association between triglyceride glucose index and its derived indices with kidney stones: a nationwide population-based study.World journal of urology · 2026Article
- Associations of the triglyceride-glucose index and its obesity-related derivatives with cardiac structure, function, and incident atrial fibrillation: a prospective cohort study using cardiac magnetic resonance.Cardiovascular diabetology · 2026Article
- The role of Western diet and gut microbiota in the pathogenesis of cardiovascular diseases.Frontiers in microbiology · 2026Review
- Association of the preoperative triglyceride-glucose index with postoperative atrial fibrillation following esophagectomy: a retrospective cohort study with a focus on non-diabetic patients.Frontiers in nutrition · 2026Article
- The associations of the triglyceride-glucose index and estimated glucose disposal rate with incident cardiometabolic multimorbidity vary across obesity phenotypes: a longitudinal cohort study.Frontiers in nutrition · 2026Article
- Development and external validation of a composite biomarker-based machine learning model for sarcopenia risk stratification in patients with cardiovascular disease.Frontiers in cardiovascular medicine · 2026Article
- Prognostic value of triglyceride-glucose index in patients with cardiovascular-kidney-metabolic syndrome undergoing percutaneous coronary intervention.Frontiers in cardiovascular medicine · 2025Article
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Abstract
backgroundThe triglyceride-glucose (TyG) related indices are simple biomarkers of insulin resistance and are associated with metabolic syndrome (MetS) and atrial fibrillation (AF). However, whether TyG-related indices are linked to all-cause and cardiovascular mortality in individuals with coexisting AF and MetS remains unclear.
methodsWe included 2535 participants with both AF and MetS from the UK Biobank. TyG-related indices, including TyG, TyG combined with body mass index (TyG-BMI), TyG combined with waist circumference (TyG-WC), and TyG combined with the waist-to-height ratio (TyG-WHtR), were calculated. The study endpoints were all-cause and cardiovascular mortality. Participants were followed until death or December 31, 2023, whichever occurred first. Associations between TyG-related indices and mortality outcomes were assessed using Cox proportional hazards models and restricted cubic spline (RCS) analyses.
resultsOver a mean follow-up period of 12.7 years (IQR: 11.8‒15.2), 956 all-cause deaths and 385 cardiovascular deaths were documented. Kaplan‒Meier survival analyses revealed the highest incidence of all-cause mortality in the fourth quartile of TyG (log-rank P < 0.001). Compared with individuals in the second quartile, individuals in the highest quartile had a significantly increased risk of all-cause mortality (TyG: hazard ratio (HR) 1.36, 95% confidence interval (CI): (1.14‒1.64); TyG-BMI: 1.31, 1.10‒1.56; TyG-WC: 1.41, 1.18‒1.68; TyG-WHtR: 1.56, 1.3‒-1.86). Moreover, TyG, TyG-BMI, and TyG-WHtR were significantly associated with cardiovascular mortality (TyG: HR 1.47, 95% CI 1.10‒1.95; TyG-WC: 1.41, 1.03‒1.93; TyG‒WHtR: 1.35, 1.01‒1.80). RCS analyses revealed nonlinear association between TyG and mortality and between TyG-BMI and all-cause mortality (all P < 0.05). The results of the sensitivity and subgroup analyses were consistent with those of the primary analyses.
conclusionsThis study demonstrateed the prognostic value of TyG-related indices in individuals with AF and MetS. These indices may serve as practical surrogate markers for risk stratification and the prevention of adverse outcomes.
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