ArticleBMC endocrine disorders2025
Correlation between 25-hydroxyvitamin D levels and remnant cholesterol in patients with type 2 diabetes.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Perioperative Cerebral Protection and Monitoring of Acute Stanford Type A Aortic Dissection: A Retrospective Cohort Study.Journal of cardiovascular development and disease · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundRemnant cholesterol (RC) is an independent predictor of cardiovascular events in type 2 diabetes mellitus (T2DM). Concurrently, vitamin D deficiency is a recognized risk factor for developing T2DM. However, the association between serum 25-hydroxyvitamin D (25(OH)D) levels and RC in patients with established T2DM remains incompletely elucidated. Specifically, potential non-linear relationships and modifications of this association by age and sex are unclear. This study investigates the relationship between 25(OH)D and RC in a cohort of 380 patients with T2DM.
methodsA total of 380 T2DM patients (283 men and 97 women) were evaluated. Demographic data were analyzed descriptively. Statistical tests assessed the association between 25(OH)D levels and RC, and piecewise linear regression was utilized to explore potential threshold effects.
resultsSpearman correlation analysis revealed that female gender was significantly associated with higher RC levels (ρ = 0.163, p = 0.002). Piecewise linear regression identified a threshold effect at 18.8 ng/mL: below this threshold, each 1 ng/mL increase in 25(OH)D was associated with a decrease in RC of 0.01 mmol/L (β = -0.01, 95% CI: -0.02 to -0.00); above this threshold, it was associated with an increase of 0.02 mmol/L (β = 0.02, 95% CI: 0.00 to 0.03).Age significantly modified this association (interaction p < 0.05), suggesting an age-dependent inversion of the effect of vitamin D on RC.
conclusionThis study demonstrates a complex, non-linear relationship between 25(OH)D levels and Remnant cholesterol in patients with type 2 diabetes. Age significantly modifies this relationship, suggesting that tailored interventions based on vitamin D status may be warranted to inform future interventional studies targeting RC modulation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.