Evidence map›Paper›PMID 41163191›Full record

ArticleJournal of orthopaedic surgery and research2025

Optimizing LED photobiomodulation parameters to prevent cartilage matrix degradation in knee osteoarthritis: in vitro and in vivo study.

Tianxiang Fan, Peng Xia, Safayet Ahmed, Yuen H Tsang, Ye Li, Siu Ngor Fu

Abstract read
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In one paragraph

Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tianxiang FanDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China.ORCID http://orcid.org/0000-0003-3781-924X
Peng XiaDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China.ORCID http://orcid.org/0000-0003-3891-3385
Safayet AhmedDepartment of Physics, Oregon State University, Corvallis, Oregon, USA.ORCID http://orcid.org/0000-0003-3292-3929
Yuen H TsangDepartment of Applied Physicals, The Hong Kong Polytechnic University, Hong Kong, China.ORCID http://orcid.org/0000-0001-5632-5224
Ye LiDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China. yeli@link.cuhk.edu.hk.ORCID http://orcid.org/0000-0002-2481-6894
Siu Ngor FuDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China. amy.fu@polyu.edu.hk.ORCID http://orcid.org/0000-0003-4405-015X

Funding

Applied Physics Departmental Grant, The Hong Kong Polytechnic University 1-WZ2WSupport related to Research Institute for Sports Science and Technology, RISports P0043199
6 · The paper itself

Abstract

backgroundPhotobiomodulation using light-emitting diode (LED) therapy is a promising and safe non-invasive approach for treating knee osteoarthritis (KOA), yet the most effective wavelength and energy density to prevent cartilage matrix degradation remain unclear. This study aimed to determine the optimal LED parameters for suppressing chondrocyte extracellular matrix (ECM) degradation in vitro, and for alleviating ECM degradation and pain-related behaviours in a murine KOA model.

methodsTNF-α-stimulated RCJ 3.1.C5.18 chondrocytes were irradiated with LEDs (625/810/940/1050 nm; 13-78 J/cm

resultsIn vitro, 940 nm LED at 52 J/cm

conclusionLED therapy at 940 nm with 52 J/cm

Indexed as

Cartilage, ArticularChondrocytesExtracellular MatrixLow-Level Light TherapyOsteoarthritis, KneeAnimalsCells, CulturedDisease Models, AnimalMaleMatrix Metalloproteinase 3MiceMice, Inbred C57BLMatrix Metalloproteinase 3CartilageKnee painLight-emitting diodeOsteoarthritisPhotobiomodulation

Identifiers

PMID41163191
PMCPMC12570694

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.