ArticleOrthopedic reviews2025
Effectiveness of hydrogel-based therapies in the treatment of talus osteoarthritis: a systematic review.
Article in Orthopedic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Talus osteoarthritis (OA) is a disabling condition that negatively affects the lives of individuals in terms of pain, functional limitation. Hydrogels, due to their viscoelastic, bioactive, and biocompatible properties, have emerged as a promising therapeutic option in cartilage repair and OA management. Currently hydrogel applications in other joint OA such as knee are extensively studied, while their use in talocrural joint degeneration remains underexplored. This systematic review aims to analyze the uncertainty in the effectiveness and safety of hydrogel-based therapies in the treatment of talus OA. Methods: Following PRISMA guidelines, a systematic search was conducted across PubMed, Embase, Scopus, Web of Science, and the Cochrane Library from 2015 up to 2025. Eligible studies included case series, cohort and randomized clinical trials investigating hydrogel implementation for talus OA. Data extraction and risk of bias assessments were independently performed by two reviewers. Thematic synthesis was applied due to heterogeneity in study designs. Results: Preliminary screening identified 5 relevant studies. Hydrogel types included hyaluronic acid derivatives. Outcomes assessed included pain scores, joint function and imaging-based structural changes. Conclusion: Hydrogel-based therapies represent a promising joint-preserving option for talus osteoarthritis, offering potential cartilage support and symptom relief. However, current evidence remains limited. Larger, well-designed clinical trials with standardized outcome measures are essential to validate efficacy and refine formulations tailored to the unique biomechanics of the ankle joint.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.