ReviewFrontiers in cell and developmental biology2025
Smart biomaterials: as active immune modulators to shape pro-regenerative microenvironments.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Injectable hydrogels for bone regeneration: from materials design to clinical translation.RSC advances · 2026Review
- 4D nanoimaging-guided smart therapeutics: spatiotemporal control of disease microenvironments.RSC advances · 2026Review
- Surviving the Nucleus Pulposus Desert: Next-Generation Strategies for Intervertebral Disc Cell Therapy.JOR spine · 2026Article
- Multifunctional VEGF/CeOPharmaceutics · 2026Article
- Hollow Glass Microspheres (HGMs): Synthesis, Characterization, and Processes in Biomedical Applications-A Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Natural Polymers in Guided Bone Regeneration (GBR).Journal of functional biomaterials · 2026Review
- Smart Nanomaterials and Natural Biologics for Innate-Adaptive Immune Reprogramming: A Nanobiotechnology Framework for Translational Medicine.Nanomaterials (Basel, Switzerland) · 2026Review
- From Nature to Innovation: Exploring Natural Biopolymers in 3D Bioprinting for Bone Regeneration.ACS omega · 2026Article
- Bioinspired and living multiscale composites for regenerative medicine in the treatment of surgical site infections.Journal of nanobiotechnology · 2026Review
- From bone replacement to regeneration. A biomaterials started journey.Materials today. Bio · 2026Review
- Review
- Biomaterial physicochemical properties govern immune activation and bone regeneration: a titanium-focused design-oriented osteoimmunological framework.Frontiers in immunology · 2026Review
- The cutting-edge advancements in biomaterials under the guidance of intelligence and bionics.Regenerative biomaterials · 2026Review
- Beyond receptor activation: biased toll-like receptor signaling in periodontal inflammation and regeneration.Frontiers in immunology · 2026Review
- Checkpoint inhibition and beyond: Precision immune engineering for the immune-privileged landscape of ocular malignancies.BioImpacts : BI · 2026Review
- Molecular pathways and immune microenvironment regulation in stem cell therapy for thin endometrium: a comprehensive narrative review.Frontiers in immunology · 2026Review
- Immune-Guided Bone Healing: The Role of Osteoimmunity in Tissue Engineering Approaches.International journal of molecular sciences · 2025Review
- Death as rebirth: how efferocytosis drives tissue repair and disease treatment.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of smart biomaterials has evolved from passive scaffolds to dynamic, immune-modulating platforms capable of actively shaping regenerative microenvironments. This review explores the transition from inert to autonomous systems, emphasizing innovations in material responsiveness-such as pH, temperature, and enzymatic sensitivity-that enable intelligent interactions with biological cues. A key focus is the role of macrophage polarization in tissue repair, where biomaterials regulate immune responses through physicochemical properties and spatiotemporally controlled immunomodulatory factor release. Applications in cancer immunotherapy, myocardial regeneration, and scar inhibition highlight their therapeutic potential. Advances in biomimetic design and multiscale modeling accelerate rational development. However, clinical translation faces challenges in biosafety, scalability, and regulatory approval. Future directions point towards precision immune engineering, integrating optogenetic control, artificial intelligence-driven personalized design, and synergistic multimodal therapies. Ultimately, smart biomaterials are pioneering precision immune engineering, offering transformative strategies for regenerative medicine and disease intervention.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.