Evidence mapPaperPMID 41164360Full record

ArticleFrontiers in nutrition2025

Impact of a food supplement containing

Alessandro Di Minno, Maria Vittoria Morone, Daniele Giuseppe Buccato, Lorenza Francesca De Lellis, Hammad Ullah, Luca Borromeo, Angela Cerqua, Roberto Piccinocchi, Agostino Greco, Salvatore Santonastaso and 8 more

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alessandro Di Minno *Department of Pharmacy, University of Napoli Federico II, Naples, Italy.
Maria Vittoria Morone *Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania "L. Vanvitelli", Naples, Italy.
Daniele Giuseppe Buccato *Department of Pharmacy, University of Napoli Federico II, Naples, Italy.
Lorenza Francesca De LellisDepartment of Pharmacy, University of Napoli Federico II, Naples, Italy.
Hammad UllahSchool of Pharmacy, University of Management and Technology, Lahore, Pakistan.
Luca BorromeoDepartment of Pharmacy, University of Napoli Federico II, Naples, Italy.
Angela CerquaDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Roberto PiccinocchiDepartment of Anaesthesia and Resuscitation A. U. O. Luigi Vanvitelli, Naples, Italy.
Agostino GrecoAzienda Sanitaria Locale Caserta, Caserta, Italy.
Salvatore SantonastasoAzienda Sanitaria Locale Caserta, Caserta, Italy.
Danaé S LarsenSchool of Chemical Sciences, The University of Auckland, Auckland, New Zealand.
Hesham El-SeediDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, Saudi Arabia.
Costanza Valentina RiccioniR&D Department, Esserre Pharma Srl, Rome, Italy.
Alessandra BaldiDepartment of Pharmacy, University of Napoli Federico II, Naples, Italy.
Gaetano PiccinocchiComegen Società Cooperativa Sociale, Naples, Italy.
Xiang XiaoSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
Roberto SacchiApplied Statistic Unit, Department of Earth and Environmental Sciences, University of Pavia, Pavia, Italy.
Maria DagliaDepartment of Pharmacy, University of Napoli Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Impaired fasting glycemia (IFG) puts carriers at a significantly higher risk of developing type 2 diabetes and cardiovascular disease. Lifestyle changes, such as increased physical activity and a healthy diet rich in fiber and low in sugar, can often reverse prediabetes and significantly reduce the risk of progressing to type 2 diabetes metabolic disorders, especially diabetes (1). Methods: This randomized clinical trial aims to evaluate the efficacy and tolerability of a food supplement (FS) containing Results: The treatment group showed a significant improvement in fasting glycemia after 3 months, with normalization of glucose levels ( Discussion: Daily intake of the tested FS in combination with an isocaloric diet significantly improved glucose and lipid metabolism, suggesting that the combination of ingredients with different mechanisms of action can be considered a valuable strategy for improving impaired fasting blood glucose and lipid profiles. Clinical trial registration: www.isrctn.com, ISRCTN15062713.

Indexed as

chromiumCitrus limon extractglucose and lipid metabolismhesperidinimpaired fasting glucoserandomized controlled trialVitis viifera extract

Identifiers

PMID41164360
PMCPMC12558782

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.