Evidence map›Paper›PMID 41164442›Full record

ArticleGlobal health & medicine2025

Coronary artery stenosis in Japanese hemophiliacs living with HIV-1 progressed dramatically over two years.

Ran Nagai, Hiroyuki Gatanaga, Haruka Uemura, Mikiko Ogata, Shuji Kubota, Masaya Yamamoto, Hisao Hara, Shinichi Oka, Yukio Hiroi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global health & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ran NagaiDepartment of Cardiology, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Hiroyuki GatanagaJoint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Haruka UemuraAIDS Clinical Center, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Mikiko OgataAIDS Clinical Center, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Shuji KubotaDepartment of Cardiology, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Masaya YamamotoDepartment of Cardiology, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Hisao HaraDepartment of Cardiology, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Shinichi OkaJoint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Yukio HiroiDepartment of Cardiology, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with hemophilia living with HIV-1 are at increased risk for coronary artery disease (CAD) due to overlapping factors, including chronic vascular inflammation, antiretroviral therapy-associated dyslipidemia, and reduced physical activity from hemophilic arthropathy. However, longitudinal data on cardiovascular outcomes in this population have been scarce. In this two-year longitudinal follow-up study, 58 patients were evaluated. The cohort was stratified into three groups based on baseline CCTA findings and treatment history: 47 with normal-to-mild stenosis, 3 with prior PCI or CABG, and 8 with moderate-to-severe stenosis. Among the moderate stenosis group, 7 underwent repeat CCTA, and 4 showed progression of coronary lesions. Of these, 3 developed severe stenosis requiring percutaneous coronary intervention (PCI), despite improvement in LDL-C through pharmacologic and lifestyle interventions. Overall, LDL-C significantly decreased (

Indexed as

coronary artery diseasecoronary computed tomography angiographyhemophiliaHIV-1pulse wave velocityvascular inflammation

Identifiers

PMID41164442
PMCPMC12560031

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.