Evidence map›Paper›PMID 41164768›Full record

Review3 Biotech2025

A comprehensive review of alkaloids in cancer therapy: focusing on molecular mechanisms and synergistic potential of piperine in colorectal cancer.

Chinthana Chidananda, Goutam Thakur, Deepanjan Datta, Ketul Popat

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in 3 Biotech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chinthana ChidanandaDepartment of Biomedical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka 576104 India.
Goutam ThakurDepartment of Biomedical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka 576104 India.ORCID 0000-0002-1449-9581
Deepanjan DattaDepartment of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka 576104 India.
Ketul PopatDepartment of Bioengineering, College of Engineering and Computing, George Mason University, Fairfax, VA 22030 USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alkaloids exhibit a wide range of anticancer activities, including the induction of apoptosis, regulation of autophagy, arrest of the cell cycle, inhibition of angiogenesis, and disruption of oncogenic signaling pathways. Among these compounds, piperine, a piperidine alkaloid derived from black pepper, demonstrates multifaceted activity against colorectal cancer (CRC). Preclinical studies indicate that piperine induces apoptosis through mitochondrial and reactive oxygen species (ROS)-mediated mechanisms, arrests the cell cycle at the G

Indexed as

AlkaloidsBlack pepperColorectal cancerCombination therapyNutraceuticalsPiperidine alkaloidPiperine

Identifiers

PMID41164768
PMCPMC12559525

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.