SynthesisThe Journal of clinical endocrinology and metabolism2026
Cardiometabolic Risk Parameters in "Nonfunctioning" Adrenal Incidentalomas: A Systematic Review and Meta-analysis.
Synthesis in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Cardiometabolic Risk Parameters in "Nonfunctioning" Adrenal Incidentalomas: A Systematic Review and Meta-analysis.The Journal of clinical endocrinology and metabolism · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSeveral studies have investigated whether patients with nonfunctioning adrenal incidentalomas (NFAI) have an increased cardiometabolic risk, based on surrogate parameters such as the augmentation index (Aix), carotid intima-media thickness (cIMT), flow-mediated dilation (FMD), insulin resistance (IR), left ventricular mass index (LVMI), and pulse wave velocity (PWV), compared to patients without adrenal incidentalomas (AI). We sought to analyze the available literature to evaluate AIx, cIMT, FMD, IR, LVMI, and PWV in patients with NFAI as compared to patients without AI.
designSystematic review and meta-analysis.
methodsWe included studies that evaluated the cIMT and IR (primary outcomes) and AIx, FMD, LVMI, and PWV (secondary outcomes) in patients with NFAI vs matched subjects without AI. A random-effects model (DerSimonian and Laird) was used to calculate the standardized mean difference and 95% CI for each outcome.
resultsAmong the 24 available studies, 21 studies provided the necessary data (2228 subjects, mean age 53.3 ± 2.9 years, 35% males). Data on cIMT, IR, AIx, FMD, LVMI, and PWV were reported in 12 (1063 subjects), 15 (1745 subjects), 2 (140 subjects), 3 (198 subjects), 3 (201 subjects), and 2 (140 subjects) studies, respectively. Compared with patients without AI, patients with NFAI showed statistically significant differences in cIMT, IR, AIx, FMD, LVMI, and PWV (standardized mean difference and 95% CI: 1.22, 0.87-1.58; 0.51, 0.32-0.69; 0.94, 0.38-1.50; -1.24, -1.84- -0.65; 0.41, 0.04-0.78; 1.03, 0.16-1.89, respectively).
conclusionBased on cIMT, IR, AIx, FMD, LVMI, and PWV levels, patients with NFAI may be at increased cardiovascular risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.