Evidence map›Paper›PMID 41165167›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2026

Cognitive and Motor Improvements Correlated with Sleep and Activity Following Community-Based Non-contact Boxing in Patients with Parkinson Disease.

Melanie Leguizamon, Paula Trujillo, Kilian Hett, Colin D McKnight, Tristan Ponzo, Jason Elenberger, Alexander K Song, Colleen Bridges, Bailu Yan, Hakmook Kang and 3 more

Abstract read
In one paragraph

Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Melanie LeguizamonDepartment of Neurology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37240, USA.ORCID 0009-0005-5721-6966
Paula TrujilloDepartment of Neurology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37240, USA.
Kilian HettDepartment of Neurology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37240, USA.
Colin D McKnightDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 2201 West End Ave, Nashville, TN 37235, USA.
Tristan PonzoDepartment of Neurology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37240, USA.
Jason ElenbergerDepartment of Neurology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37240, USA.
Alexander K SongDepartment of Neurology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37240, USA.
Colleen BridgesBridges for Parkinson's, 130 Seaboard Ln STE A4, Franklin, TN 37067, USA.
Bailu YanDepartment of Biostatistics, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 1100 Nashville, TN 37203-1741, USA.
Hakmook KangDepartment of Biostatistics, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 1100 Nashville, TN 37203-1741, USA.
Manus J DonahueDepartment of Neurology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37240, USA.
Daniel O ClaassenDepartment of Neurology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37240, USA.
Ciaran M ConsidineDepartment of Neurology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37240, USA.

Funding

Quantification of Glymphatic Dysfunction in Patients with Alzheimer's Disease and Related DementiasR01NR015079 · NINR · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DONAHUE, MANUS J · 2014 to 2022
$3.9M
Quantitative Imaging of Brain Glymphatic Function in HumansR01AG062574 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAASSEN, DANIEL OLIVER, DONAHUE, MANUS J · 2020 to 2024
$3.0M
Quantitative imaging of choroid plexus function and neurofluid circulation in Alzheimer's Disease Related DementiaR01AG083159 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Manus J Donahue · 2023 to 2026
$2.3M
NIA NIH HHS R01 AG062574NIA NIH HHS R01 AG083159NINR NIH HHS R01 NR015079U.S. Department of Defense 12719996
6 · The paper itself

Abstract

objectiveTo evaluate the feasibility of a 12-week community-based, non-contact rock-steady-boxing (RSB) program in individuals with Parkinson disease (PD) and to assess potential improvements in motor and cognitive functioning after intervention.

methodOver 12 weeks, 26 PD participants completed 24 RSB classes. Motor and cognitive assessments were conducted at baseline and follow-up, with a sub-group (n = 14) wearing clinical actigraphy. Linear mixed-effects models investigated compliance and changes in motor and cognitive functions. Multiple linear regression assessed correlations of clinical changes with clinicodemographic factors and actigraphy variables (two-sided p < .05).

resultsPD participants showed significantly improved motor performance on the Mini Balance Evaluation Systems Test following RSB (p < .01, β = 0.69, 95% C.I. [0.40, 0.99]). No significant cognitive improvements were observed after false discovery correction, though higher scores with moderate effect sizes were suggested on HVLT-Total Recall (p = .23, β = 0.30, 95% C.I. [0.033, 0.58]), HVLT-Delayed Recall (p = .23, β = 0.25, 95% C.I. [0.03,0.46]), Stroop-Color (p = .23, β = 0.26, 95% C.I. [0.04, 0.48]), and Stroop-Interference tests (p = .15, β = 0.39, 95% C.I. [0.13, 0.64]). No significant changes were observed for actigraphy-based activity and sleep metrics. Exploratory analysis provided effect sizes and confidence intervals of associations between actigraphy variables and clinical assessments.

conclusionsRSB intervention led to better motor functioning and potential, though uncertain, cognitive benefits independent of age, sex, or disease severity. Cautious interpretation of exploratory analyses suggests changes in activity and sleep may relate to motor and cognitive changes following RSB. Findings support compliance with RSB in PD and motivate larger, randomized trials investigating the role of exercise in facilitating PD symptom improvement.

Indexed as

CognitionExercise TherapyParkinson DiseaseSleepActigraphyAgedFeasibility StudiesFemaleHumansMaleMiddle AgedActigraphyBoxingCognitionExerciseParkinson diseaseSleep

Identifiers

PMID41165167
PMCPMC13178670

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.