Evidence map›Paper›PMID 41165399›Full record

Trial reportJournal of cellular and molecular medicine2025

Association of Triglyceride-Glucose Index With Different Cardiovascular Diseases in Non-Diabetic Hypertension.

Qiyu Xiao, Xiaoying Li, Xi Zhou, Zhengbin Yao, Rui He, Yong Long, Yingjie Su

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiyu XiaoDepartment of Nuclear Medicine, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, China.
Xiaoying LiDepartment of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Xi ZhouDepartment of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Zhengbin YaoDepartment of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Rui HeDepartment of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Yong LongDepartment of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Yingjie SuDepartment of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

Funding

Health Research Project of Hunan Provincial Health Commission 20254719Scientific Research Project of Changsha Health Commission
6 · The paper itself

Abstract

This research intends to explore the association of the triglyceride-glucose (TyG) index with cardiovascular disease (CVD) death, stroke, myocardial infarction (MI), heart failure (HF) and peripheral arterial disease (PAD) in non-diabetic hypertension. This post hoc analysis uses data from a large-scale randomised controlled trial (RCT) study-Systolic Blood Pressure Intervention Trial (SPRINT), and we used Cox proportional hazards regression to explore the relationship between TyG and different CVDs. This longitudinal analysis of 9323 participants revealed a significant positive association between the TyG index and CVD death (HR 1.91, 95% CI 1.34, 2.73), HF (HR 1.43, 95% CI 1.05, 1.94), MI (HR 1.30, 95% CI 1.00, 1.69), stroke (HR 1.60, 95% CI 1.16, 2.21) and PAD (HR 1.78, 95% CI 1.30, 2.44). This positive correlation was consistently observed across different subgroups. Trend tests were significant for CVD death, heart failure, MI, stroke and PAD (p < 0.05). In non-diabetic hypertensive patients, a higher TyG index was associated with a higher risk of CVD (CVD death, stroke, HF, MI, PAD).

Indexed as

Blood GlucoseCardiovascular DiseasesHypertensionTriglyceridesAgedFemaleHeart FailureHumansMaleMiddle AgedProportional Hazards ModelsRisk FactorsBlood GlucoseTriglyceridescardiovascular diseasehypertensionperipheral arterial diseasestroketriglyceride–glucose index

Identifiers

PMID41165399
PMCPMC12573475

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.