SynthesisAging clinical and experimental research2025
Effects of protein-based multinutrient therapy on sarcopenia in older adults: a systematic review and meta-analysis.
Synthesis in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Exercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review.The journal of nutrition, health & aging · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundSarcopenia is characterized by progressive loss of muscle strength, mass, and function, representing a major public health concern, particularly in aging populations. According to incomplete statistics, approximately 10-30% of older adults worldwide are affected by sarcopenia, this health issue has imposed substantial impacts on global public health systems and economic burdens. Due to the disease’s multifactorial pathogenesis, no targeted pharmacotherapies currently exist. Research indicates that nutritional intervention, as a complementary alternative therapy, promotes muscle protein synthesis and maintains musculoskeletal health. However, the efficacy of nutritional therapy remains controversial due to sarcopenia’s multifactorial etiology.
objectiveThis study systematically evaluates the therapeutic efficacy of protein-based multinutritional interventions for sarcopenia through a high-quality meta-analysis.
methodsWe systematically searched electronic databases from inception to January 6, 2025, including PubMed, EMBASE, Web of Science, Scopus, Ovid/MEDLINE, and ProQuest. Randomized controlled trials (RCTs) meeting the inclusion criteria were subjected to meta-analysis using STATA 17.0 for statistical computations.
resultsA total of 10 studies involving 1,359 participants with intervention durations ranging from 12 to 48 weeks were included. The meta-analysis demonstrated significant improvements with nutritional therapy: handgrip strength (HGS) (MD = 0.33 kg, 95% CI: 0.07 to 0.60), gait speed (GS) (MD = 0.15 m/s, 95% CI: 0.03 to 0.28), and Insulin-like Growth Factor-1 (IGF-1) levels (MD = 0.49 ng/mL, 95% CI: 0.33 to 0.65). Compared to placebo, no statistically significant differences were observed for Short Physical Performance Battery (SPPB) (SMD = 0.06, 95% CI: -0.12 to 0.23), chair-stand time (MD = -0.15 s, 95% CI: -0.37 to 0.07), or Skeletal Muscle Index (SMI) (MD = 0.61 kg/m², 95% CI: -0.41 to 1.64).
conclusionsProtein-based multinutrient therapy significantly improved HGS, GS, and IGF-1 levels in patients with sarcopenia, but showed no significant effects on SPPB scores, chair-stand time, or SMI. The included studies were generally of high quality, and the results are relatively reliable, however, more high-quality RCTs are needed for further validation.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.