Evidence map›Paper›PMID 41167655›Full record

ArticleIn vivo (Athens, Greece)

Functional Abdominal Bloating Is Associated With Gut Microbiota Dysbiosis and Altered Intestinal Barrier Function: Experimental Evidence.

Deniz Sunnetci Akkoyunlu, Altay Celebi, Bahriye Gur, Aylin Kanli, Cansu Ugurtas, Tolgahan Ozer, Nurhan Kulcu Sarikaya, Seda Eren Keskin, Naci Cine, Hakan Savli

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Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deniz Sunnetci AkkoyunluDepartment of Medical Genetics, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
Altay CelebiDepartment of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
Bahriye GurDepartment of Medical Genetics, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
Aylin KanliDepartment of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye; aylin.kanli@kocaeli.edu.tr.
Cansu UgurtasDepartment of Medical Genetics and Molecular Biology, Institute of Health Sciences, Kocaeli University, Kocaeli, Türkiye.
Tolgahan OzerDepartment of Medical Genetics, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
Nurhan Kulcu SarikayaDepartment of Medical Services and Techniques, Vocational School of Health Services, Kocaeli University, Kocaeli, Türkiye.
Seda Eren KeskinDepartment of Medical Genetics, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
Naci CineDepartment of Medical Genetics, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
Hakan SavliDepartment of Medical Genetics, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThis study aimed to characterize gut microbiota alterations and intestinal barrier markers in patients with functional abdominal bloating (FAB) to explore its underlying biological mechanisms. MATERIALS AND

methodsStool samples from 42 adults diagnosed with FAB per Rome IV criteria were analyzed using the intergenic spacer profiling, which profiles the

resultsA dysbiosis index ≥15 was observed in 90.5% of patients, indicating significant microbial imbalance. Most showed a low mean

conclusionThis study demonstrates that FAB is accompanied by profound alterations in gut microbiota composition and mucosal immune responses, indicating that its pathophysiology extends beyond functional disturbances to include measurable biological changes. These findings support the growing clinical relevance of microbiota-informed evaluation and open new avenues for targeted therapeutic strategies.

Indexed as

DysbiosisGastrointestinal MicrobiomeIntestinal MucosaAdultAgedBacteriaBiomarkersFecesFemaleHumansIntestinal Barrier FunctionMaleMiddle AgedRNA, Ribosomal, 16SBiomarkersRNA, Ribosomal, 16SdysbiosisFirmicutes/Bacteroidetes ratioFunctional abdominal bloatinggut microbiotamicrobiome

Identifiers

PMID41167655
PMCPMC12588231

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.