ArticleIn vivo (Athens, Greece)
Tripartite Motif-containing 22 Is Involved in TLR3-mediated Inflammatory Pathway in Rheumatoid Fibroblast-like Synoviocytes.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Induced Regulatory T Cells Attenuate Poly I:C-Triggered Acute Lung Injury by Modulating Cytokine Responses.Journal of immunology research · 2026Article
- Negative Regulator of Interferon Response Promotes Toll-like Receptor 3-induced Interleukin 6 in Rheumatoid Synoviocyte.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimRheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and cartilage destruction. Tripartite motif-containing 22 (TRIM22) is involved in intracellular signal transduction, protein regulation, and innate immunity through E3 ubiquitin ligase activity. In this study, we examined the expression of TRIM22 and its potential role in synovial inflammation in RA. MATERIALS AND
methodsHuman rheumatoid fibroblast-like synoviocytes (RFLS) were cultured and treated with polyinosinic:polycytidylic acid (poly I:C), a toll-like receptor 3 (TLR3) ligand. Poly I:C was applied at different concentrations for different treatment durations. RNA interference was performed by pre-treating RFLS with either non-silencing control small interfering RNA (siRNA) or siRNA targeting
results
conclusionTreatment of cultured RFLS with a TLR3 agonist led to the upregulation of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.