ArticleIn vivo (Athens, Greece)
Wheel Running in Digital Ventilated Cages
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
BACKGROUND/
aimCancer-induced bone pain (CIBP) due to metastatic breast cancer is common and debilitating. Effective, long-term treatment options have side-effects that reduce patients' quality of life. Preclinical models are valuable tools for testing novel analgesics, but new methods that are translationally and clinically relevant are necessary. This study aimed to assess spontaneous pain-like behavior of home cage activity and wheel running in Digital Ventilated Cages MATERIALS AND
methodsTwenty BALB/cAnNHsd mice were housed in Digital Ventilated Cages
resultsThe 4T1-Luc2-inoculated mice displayed pain-like behavior in limb-use and weight-bearing tests, demonstrating a preference for the contralateral limb. The limb-use scores were compared with home cage activity and wheel running. Reduced wheel running distance corresponded to reduced limb-use scores, with the shortest wheel running distances corresponding to the lowest scores. However, this behavioral pattern was not observed in home-cage activity, which remained consistent throughout the study.
conclusionWheel running behavior appears to be affected by the development of metastatic breast cancer. Wheel running in a Digital Ventilated Cage
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