Evidence map›Paper›PMID 41168240›Full record

ArticleScientific reports2025

Poly-L-Ornithine coated plant scaffolds support motor recovery in rats after traumatic spinal cord injury.

Lauren J Couvrette, Krystal L A Walker, Arman Bayat, Daniel J Modulevsky, Alex M Laliberté, Charles M Cuerrier, Maxime Leblanc-Latour, Ryan J Hickey, Rose Boudria, Ruthie Monty and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lauren J CouvretteDepartment of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie, Ottawa, ON, K1N5N5, Canada.
Krystal L A WalkerDepartment of Physics, University of Ottawa, STEM Complex, 150 Louis Pasteur Pvt., Ottawa, ON, K1N5N5, Canada.
Arman BayatDepartment of Physics, University of Ottawa, STEM Complex, 150 Louis Pasteur Pvt., Ottawa, ON, K1N5N5, Canada.
Daniel J ModulevskyDepartment of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie, Ottawa, ON, K1N5N5, Canada.
Alex M LalibertéDepartment of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie, Ottawa, ON, K1N5N5, Canada.
Charles M CuerrierDepartment of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie, Ottawa, ON, K1N5N5, Canada.
Maxime Leblanc-LatourDepartment of Physics, University of Ottawa, STEM Complex, 150 Louis Pasteur Pvt., Ottawa, ON, K1N5N5, Canada.
Ryan J HickeyDepartment of Physics, University of Ottawa, STEM Complex, 150 Louis Pasteur Pvt., Ottawa, ON, K1N5N5, Canada.
Rose BoudriaDepartment of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie, Ottawa, ON, K1N5N5, Canada.
Ruthie MontyDepartment of Physics, University of Ottawa, STEM Complex, 150 Louis Pasteur Pvt., Ottawa, ON, K1N5N5, Canada.
Ras-Jeevan K ObhiDepartment of Physics, University of Ottawa, STEM Complex, 150 Louis Pasteur Pvt., Ottawa, ON, K1N5N5, Canada.
Isabel ShoreDepartment of Physics, University of Ottawa, STEM Complex, 150 Louis Pasteur Pvt., Ottawa, ON, K1N5N5, Canada.
Ahmad GalutaProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, K1Y 4E9, Canada.
Eve C TsaiProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, K1Y 4E9, Canada.
Tuan V BuiDepartment of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie, Ottawa, ON, K1N5N5, Canada.
Andrew E PellingDepartment of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie, Ottawa, ON, K1N5N5, Canada. apelling@uottawa.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a debilitating neurological condition with far-reaching consequences for patients, including loss of motor function and significant limitations to quality of life. Implantable biomaterials have emerged as a therapeutic strategy to modulate the SCI microenvironment and facilitate regeneration of axons. In this study, plant-derived lignocellulosic scaffolds coated with poly-L-ornithine (PLO) are shown to support locomotor recovery and neural tissue repair in a rat model of spinal cord injury. Upon complete transection of the spinal cord, animals were implanted with a plant-derived scaffold coated in PLO, a positively charged amino acid chain that is known to promote neural stem cell differentiation into neurons and enhance myelin regeneration. Recovery of motor function was evaluated by the Basso, Beattie and Bresnahan (BBB) locomotor scale as well as the Karolinska Institutet Swim Assessment Tool (KSAT). Retrograde tracing of ascending sensory tracts revealed enhanced regeneration in animals that received the PLO-coated scaffold. Numerous β-III tubulin and neurofilament 200 positive fibers may indicate axonal sprouting within the lignocellulosic scaffold and LFB staining highlights myelination around the PLO-coated scaffold. These results demonstrate the potential of plant-based biomaterials in a rat model of acute spinal cord injury and highlight their enhancement after PLO functionalization.

Indexed as

Recovery of FunctionSpinal Cord InjuriesTissue ScaffoldsAnimalsDisease Models, AnimalFemaleMotor ActivityNerve RegenerationRatsRats, Sprague-Dawley

Identifiers

PMID41168240
PMCPMC12575751

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.