ArticleNature microbiology2025
Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus.
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Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
38 authors.
Gregory A Phelps *Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-5862-5212
Sinem Kurt *Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-8410-9278
Alexander R JennerDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Shelby M AndersonDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Thalina D JayasingheDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Elizabeth C GriffithDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Carl W ThompsonDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Lei YangDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Basil WickiDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-4801-7536
Frederick K BrightDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0009-0000-6285-6718
Victoria LoudonDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
William C WrightDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-2274-9966
Ashish SrivastavaDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-7785-6718
Amarinder SinghDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
Bhargavi ThalluriDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
Hyunseo ParkDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
Robin B LeeDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Anna K WrightDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0009-0005-3817-8984
Oliver Grant-ChapmanGraduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0009-0005-1453-5860
Daryl K ConnerNTM Center, Mycobacteria Research Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0009-0008-4342-5494
Brennen T TroyerNTM Center, Mycobacteria Research Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0009-0009-1197-1391
Amy IversonDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jason OchoadoDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Vishwajeeth R PagalaCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Long WuCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Stephanie ByrumCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yingxue FuCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Zu-Fei YuanCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Anthony A HighCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-2323-5649
Bettina SchulthessInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Jason W RoschDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-1798-1760
Paul GeeleherDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Sven N HobbieDivision of Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-9205-0384
Lucas BoeckDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1442-9073
Bernd MeibohmDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-3923-3648
Andres Obregon-HenaoNTM Center, Mycobacteria Research Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA.
Peter SanderInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland. psander@imm.uzh.ch.ORCID http://orcid.org/0000-0003-1581-0682
Richard E LeeDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA. Richard.Lee@StJude.org.ORCID http://orcid.org/0000-0002-2397-0443
Funding
Spectinomycin analogs for NTM infectionsR01AI157312 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI LEE, RICHARD E. · 2020 to 2024
$4.1MTargeting NuoD for the treatment of H. pyloriR01AI170765 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Michael LaFleur, Richard E. Lee · 2023 to 2026
$3.4MTofacitinib Analogs as Oxacillin Potentiators against MRSAF31AI169961 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC · PI PHELPS, GREGORY A · 2023 to 2024
$80kAmerican Lebanese Syrian Associated Charities (ALSAC) AI157312Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) AI157312Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) AI169961NIAID NIH HHS F31 AI169961NIAID NIH HHS L70 AI172073NIAID NIH HHS R01 AI157312NIAID NIH HHS R01 AI170765Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_197699/1Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 320030 215557U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI157312U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI170765
Abstract
Non-tuberculous mycobacteria are emerging pathogens with high intrinsic drug resistance. Among these, Mycobacterium abscessus is particularly refractory owing to its extensive array of resistance mechanisms. Here we introduce florfenicol amine (FF-NH
Indexed as
Anti-Bacterial AgentsDrug Resistance, BacterialMycobacterium abscessusProdrugsThiamphenicolAnimalsBacterial ProteinsHumansMiceMicrobial Sensitivity TestsMycobacterium Infections, NontuberculousTranscription FactorsAnti-Bacterial AgentsBacterial Proteinsflorfenicol amineProdrugsThiamphenicolTranscription Factors
Identifiers
What Socratic holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.