Evidence map›Paper›PMID 41168976›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Modulating a Massive Set of Biomolecular Structures by Sono-Mechanical Force.

Pravin Pokhrel, Grinsun Sharma, Jaren Jenyk, Alyssa Lower, Jiahao Ji, Sajan Shakya, Joseph Haun, Hanbin Mao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mechanozyme: An Artificial Enzyme With a Mechanophore Framework.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Modulating a Massive Set of Biomolecular Structures by Sono-Mechanical Force.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pravin PokhrelDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.ORCID https://orcid.org/0000-0003-4259-6087
Grinsun SharmaSchool of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA.
Jaren JenykDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
Alyssa LowerThe College of Wooster, Wooster, OH, 44691, USA.
Jiahao JiDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
Sajan ShakyaDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
Joseph HaunDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
Hanbin MaoDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.ORCID https://orcid.org/0000-0002-6720-9429

Funding

Supplemental Request for Mechanical Modulation of Cell Migrations by DNA NanoassembliesR01CA252827 · NCI · KENT STATE UNIVERSITY · PI Hanbin Mao · 2023 to 2026
$1.4M
National Science Foundation CHE-2247709NCI NIH HHS R01 CA252827NIH HHS R01 CA252827
6 · The paper itself

Abstract

Mechanical modulation of biomolecular structures by single-molecule techniques, such as optical tweezers, has revealed subtle conformational dynamics and enabled precise modulation of functional properties. However, such tools are limited to manipulating one or a few molecules at a time in extracellular settings, posing significant challenges for scaling force-based methods to achieve high sensitivity and efficacy both outside and within cells. Here, low-power (<5.3 mW cm

Indexed as

DNASonicationDoxorubicinG-QuadruplexesHumansOptical TweezersDNADoxorubicinDNA G‐quadruplexDNA hairpinssono‐deliverysono‐mechanicsultrasound

Identifiers

PMID41168976
PMCPMC12806404

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.