Evidence map›Paper›PMID 41169113›Full record

ArticleACS applied materials & interfaces2025

Smart Inhalation Therapy: Boosting siRNA Efficacy with Inulin-Based Multifunctional Polymers.

Salvatore E Drago, Marta Cabibbo, Cinzia Scialabba, Emanuela F Craparo, Gennara Cavallaro

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Salvatore E DragoLab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo 90123, Italy.
Marta CabibboLab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo 90123, Italy.ORCID 0000-0002-6244-9183
Cinzia ScialabbaLab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo 90123, Italy.ORCID 0000-0002-5209-9319
Emanuela F CraparoLab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo 90123, Italy.ORCID 0000-0002-0503-9559
Gennara CavallaroLab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo 90123, Italy.ORCID 0000-0003-0585-6564

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic delivery of siRNA via inhalation holds significant promise for managing severe pulmonary diseases. However, an effective delivery platform capable of overcoming the lung's physical and biological barriers is essential to achieve efficient gene silencing in the airway epithelium. Here, we describe the synthesis of an inulin (INU)-based copolymer, INU-VS-

Indexed as

InulinPolymersRNA, Small InterferingAdministration, InhalationGene SilencingHumansInulinPolymersRNA, Small Interferinginulinlung deliverymuco-diffusionpolymethyloxazolinesiRNA

Identifiers

PMID41169113
PMCPMC12616608

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.