ArticleFrontiers in endocrinology2025
Construction and validation of a multimodal predictive model incorporating catecholamines and uric acid for early detection of hypertensive organ damage.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the feasibility and clinical value of constructing a predictive model for early detection of organ damage in hypertensive patients based on catecholamine-related indicators (norepinephrine, normetanephrine, and metanephrine), serum uric acid, and other clinical parameters. Methods: A total of 421 hypertensive patients were enrolled and divided into a training set ( Results: The incidence of organ damage was 44.07% (130/295) in the training set and 42.06% (53/126) in the validation set. Multivariate regression revealed that norepinephrine, normetanephrine, metanephrine, serum uric acid, serum creatinine, duration of hypertension, and cystatin C were independent predictors of organ damage (all Conclusion: The predictive model constructed based on relevant indicators such as catecholamines and serum uric acid in this study can effectively predict the risk of organ damage in hypertensive patients, intervene early, and provide a quantitative basis for clinical decision-making.
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