ArticleResearch and practice in thrombosis and haemostasis2025
Repeated measures of coffee consumption and risk of future incident venous thromboembolism-the Trøndelag Health Study and the Tromsø study.
Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: A limited number of epidemiological studies have reported mixed results on the association between coffee consumption and risk of venous thromboembolism (VTE). Objectives: We aimed to investigate the association between repeated measures of coffee consumption over time and risk of incident VTE in a large population-based cohort. Methods: Participants ( Results: There were 178,696 observation periods and 3419 VTEs during follow-up. A threshold effect was observed, and those who drank 1 to 2 cups of coffee per day had 21% lower risk of overall VTE (HR, 0.79; 95% CI, 0.68-0.93) than nonconsumers. The inverse association of coffee consumption (1-2 cups/d) with VTE was more pronounced for pulmonary embolism (HR, 0.72; 95% CI, 0.58-0.89) than for deep vein thrombosis (HR, 0.87; 95% CI, 0.70-1.09). The HRs for VTE remained similar across categories of higher coffee consumption after adjustments for major potential confounders. The association of coffee consumption with VTE risk was similar in women and men. Conclusion: Coffee consumption was associated with a nonlinear lower risk of overall VTE and, in particular, pulmonary embolism.
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