ArticleCureus2025
Prevalence of Multidrug-Resistant Gram-Negative Bacilli Causing Neonatal Sepsis: A Retrospective Study in a Tertiary Care Hospital From Eastern India.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Risk factors for multidrug resistance and mortality in healthcare-associated neonatal gram-negative bloodstream infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonatal sepsis is considered one of the major causes of morbidity and mortality in low and middle-income countries, with a rising burden of multidrug-resistant (MDR) gram-negative bacilli (GNB). The emergence of antimicrobial resistance (AMR) has significantly compromised treatment outcomes in neonatal intensive care units (NICUs). This study aimed to determine the prevalence, antibacterial susceptibility patterns, and associated risk factors of MDR GNB among septic neonates over a four-year period. MATERIALS AND
methodsA retrospective study was carried out from January 2021 to December 2024 in a tertiary care health setting in India. Data regarding septic neonates were retrieved from NICU records, and culture details were retrieved from the LIS (laboratory information system). Blood and cerebrospinal fluid (CSF) samples from neonates with clinically suspected sepsis were processed using the BACT/ALERT® three-dimensional (3D) system (bioMérieux SA, Marcy-l'Étoile, France). Identification and antibiotic sensitivity testing were done by the VITEK® 2 Compact automated system (bioMérieux SA), and interpretation was done as per standard microbiological protocol. Demographic, clinical, and bacterial profile data were analysed using the IBM SPSS Statistics for Windows, version 27.0 (IBM Corp., Armonk, New York, United States) Results: Altogether 2,670 neonates were admitted to the NICU during the study period. Out of 424 culture-positive samples, 201 (47.4%) were gram-negative isolates. The most prevalent bacteria were
conclusionThe findings highlight the predominance of MDR GNB in neonatal sepsis and emphasize the need for species-specific antibiotic strategies with continuous resistance monitoring.
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