ArticleFrontiers in cellular and infection microbiology2025
Infection of prepubertal heifer calves as a natural host model for
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: Four independent cohorts of cross-bred prepubertal heifer calves were vaginally inoculated with Results: Our experiments revealed that despite being in anestrus, heifer calves were amenable to infection with trophozoites for as long as 42 days post-infection as determined by PCR and culture of the organism. Histopathology revealed inflammation throughout the reproductive tract of infected calves. Infection resulted in endometritis with lymphoplasmacytic infiltration and demonstrated that trophozoites could pass through the cervix even during anestrus in prepubescent heifers. In addition, immunohistochemistry of the vagina, cervix, and uterus demonstrated robust expression of galectin-1. Conclusion: Our experiments demonstrated that prepubertal heifer calves are a suitable natural host model for bovine trichomonosis. This is a significant breakthrough in the field and also has potential for advancing the human trichomoniasis research agenda.
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