ArticleFrontiers in nutrition2025
Metabolic syndrome worsens sarcopenia and reduces nutritional therapy benefits in advanced gastric cancer.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Emerging evidence suggests metabolic syndrome (MetS) exacerbates sarcopenia progression and compromises nutritional interventions, yet its dual role as both etiological driver and therapeutic effect modifier remains uncharacterized. This study investigated MetS-related sarcopenia pathophysiology and assessed its impact on nutritional therapy efficacy in advanced gastric cancer. Patients and methods: We conducted a dual-phase investigation combining Mendelian randomization (MR) analysis of European-ancestry GWAS data ( Results: MR analysis of MetS components identified paradoxical causal effects: waist circumference increased appendicular lean mass (OR = 1.480, Conclusion: The integration of genetic and clinical findings shows that MetS components causally contribute to sarcopenia pathogenesis, and that the composite MetS phenotype confers nutritional therapy resistance. This establishes MetS's dual role as a driver of disease and a modifier of treatment efficacy.
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